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Treatment of Cancer with Dissolving Microneedles Array Using Immunomodulators and Antigens
Oui Bo WHANG,Su Yeon LIM,Da Whun KIM,Siyan LYN,Byung Deok KIM,Chae Eun PARK,Ji Hoon JEONG 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
A Microneedle (MN) is a micron-sized needle that can penetrate directly through the epidermal layer to the skin tissue without pain. As a therapeutic agent, MNs are widely used in transdermal drug delivery system (TDDS) because they are convenient, reduce side effect, and painless. Many kinds of MNs have been applied for deliver anti-cancer drug, gene or protein. In recent years, Dissolving MNs (DMNs) are studied for targeting cancer cells. Using dissolving MNs not only improves the drug bioavailability, but also reduces the first-pass effect on the liver. Imidazoquinoline is used for anti-allergic and anti-viral immune-modulator in a way to regulate immune response. In this study, we report pluronic-based DMNs which could form nano sized micelles with the hydrophobic molecule. Here, resiquimod (R848) and ovalbumin (OVA) were encapsulated in the DMNs to treat cancer. Treatment with DMNs containing adjuvant (R848) and antigen (OVA) to the skin of EG7-OVA tumor-injected mice, induced a significant level of antigen-specific humoral and cellular immunity, resulting in significant anti-cancer activity.
Siyan LYU,Su Yeon LIM,Byung Deok KIM,Da Whun KIM,Chae Eun PARK,Oui Bo WHANG,Ji Hoon JEONG 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Among the various material, poly (lactic-co-glycolic acid) (PLGA) is mainly used in the formation of sustained release microspheres due to its biodegradability, compatibility, and safety. In this study, we confirmed the treatment ability of AMD, a diease which is caused by vascular endothelial growth factor (VEGF) signaling system, by using the PLGA sustained release of microspheres. The anti-VEGF drug, Rivoceranib was encapsulated through o/w single emulsion and solvent evaporation method with polymeric excipients PLGA. In vivo study, the treatment of microspheres of PLGA/rivoceranib significantly inhibits the occurrence and spread of new blood vessels in the macular degeneration model. These results suggest that the treatment of sustained release microsphere with rivoceranib can be one strategy to treat the wet AMD through drug repositioning.