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SAMER HASAN HUSSEIN-AL-ALI,Palanisamy Arulselvan,Sharida Fakurazi,Maznah Ismail,DENA DORNIANI,MOHD ZOBIR HUSSEIN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.2
Magnetic nanoparticles (MNPs) were prepared by the coprecipitation method using a molar ratioof Fe 3 þ:Fe 2 þof 2:1. The surface of MNP was coated with chitosan (CS) and polyethylene glycol(PEG) to form CS – MNP and PEG – MNP nanoparticles, respectively. Anthranilic acid (AA) wasloaded on the surface of the resulting nanoparticles to form AA – CS – MNP and AA – PEG – MNPnanocomposites, respectively. The nanocomposites obtained were characterized using powderX-ray di®raction (XRD), Fourier transform infrared spectroscopy (FTIR), thermogravimetryanalysis (TGA), vibrating sample magnetometer (VSM) and scanning electron microscopy (SEM). XRD results showed that the as-synthesized nanocomposites are pure magnetite. FTIRresults analysis indicated the existence of two polymers on the particle surface of the MNP andthe presence of loaded AA on the surface of CS – MNP and PEG – MNP nanoparticles. Anthranilicacid loading and the release pro¯les of AA – CS – MNP and AA – PEG – MNP nanocompositesshowed that up to 8.8% and 5.5% of the adsorbed drug were released in 670 min and 771 min,respectively. Anthranilic acid release pro¯les followed a pseudo-second-order kinetic controlledprocess. The cytotoxicity of the as-synthesized anthranilic acid nanocomposities were determinedusing MTT assay using murine macrophage RAW 264.7 cells. MTT results showed that thecytotoxic e®ects of AA – CS – MNP were higher than AA – PEG – MNP against the tested cells ascompared to free anthranilic acid. In this manner, this study introduces novel anthranilic acidnanocomposites that can be used on-demand for biomedical applications.