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Sawair, F,Hassona, Y,Irwin, C,Stephenson, M,Hamilton, P,Maxwell, P,Gordon, D,Leonard, A,Napier, S Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3
Background: Expression of p53, cyclin D1, p21 (WAF1) and Ki-67 (MIB1) was evaluated in oral squamous cell carcinoma (OSCC) to test whether levels of these markers at invasive tumour fronts (ITFs) could predict the development of local recurrence. Materials and Methods: Archived paraffin-embedded specimens from 51 patients with T1/T2 tumours were stained immunohistochemically and analysed quantitatively. Local recurrence-free survival was tested with Kaplan-Meier survival plots (log-rank test) using median values to define low and high expression groups and with a Cox's proportional hazards model in which the expression scores were entered as continuous variables. Results: The assessment of expression of all markers was highly reliable, univariate analysis showing that patients with clear surgical margins, with low cyclin D1 and high p21 expression at the ITF had the best local recurrence-free survival. Multivariate analysis showed that these three parameters were independent prognostic factors but that neither p53 nor MIB1 expression were of prognostic value. Conclusions: Assessment of p53, cyclin D1, p21 (WAF1), and Ki-67 (MIB1) at the ITF could help to predict local recurrence in early stage oral squamous cell carcinoma cases.
Chaluvally-Raghavan, P.,Zhang, F.,Pradeep, S.,Hamilton, Mark P.,Zhao, X.,Rupaimoole, R.,Moss, T.,Lu, Y.,Yu, S.,Pecot, Chad V.,Aure, Miriam R.,Peuget, S.,Rodriguez-Aguayo, C.,Han, H.D.,Zhang, D.,Venkat Cell Press 2014 CANCER CELL Vol.26 No.6
Small noncoding miRNAs represent underexplored targets of genomic aberrations and emerging therapeutic targets. The 3q26.2 amplicon is among the most frequent genomic aberrations in multiple cancer lineages including ovarian and breast cancers. We demonstrate that hsa-miR-569 (hereafter designated as miR569), which is overexpressed in a subset of ovarian and breast cancers, at least in part due to the 3q26.2 amplicon, alters cell survival and proliferation. Downregulation of TP53INP1 expression by miR569 is required for the effects of miR569 on survival and proliferation. Targeting miR569 sensitizes ovarian and breast cancer cells overexpressing miR569 to cisplatin by increasing cell death both in vitro and in vivo. Thus targeting miR569 could potentially benefit patients with the 3q26.2 amplicon and subsequent miR569 elevation.
Light-Induced Absorption and Holographic Recording in Pr:LiNbO3
Van-Thai Pham,임기수,D. S. Hamilton,Minh-Tuan Trinh,이선균 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.2I
With ultraviolet illumination, we have found a broad UV-induced absorption in the blue and some involvement of Pr ions in Pr:LiNbO3. Transient and stable absorption induced by UV illumination was analyzed at 457, 514, and 633 nm and could be explained by hole trap centers and iron ions. We also studied the effects of UV illumination and boundary conditions during holographic recording in the visible. In ultraviolet-gated short-circuit holographic recording, we obtained a high sensitivity and a high diffraction efficiency.