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Cruz Martí,nez, Cindy,Diaz Gó,mez, Martha,Oh, Myung Sook SWETS AND ZEITLINGER 2017 PHARMACEUTICAL BIOLOGY Vol.55 No.1
<P><B>Abstract</B></P><P><B>Context:</B> Herbal therapies are used worldwide to treat health conditions. In Mexico, generations have used them to treat gingivitis, periodontitis, mouth infections, and discoloured teeth. However, few studies have collected scientific evidence on their effects.</P><P><B>Objective:</B> This study aimed at searching and compiling scientific evidence of alternative oral and dental treatments using medicinal herbs from Mexico.</P><P><B>Methods:</B> We collected various Mexican medicinal plants used in the dental treatment from the database of the Institute of Biology at the National Autonomous University of Mexico. To correlate with existing scientific evidence, we used the PubMed database with the key term ‘(scientific name) and (oral or dental)’.</P><P><B>Results:</B> Mexico has various medical herbs with antibacterial and antimicrobial properties, according to ancestral medicinal books and healers. Despite a paucity of experimental research demonstrating the antibacterial, antimicrobial, and antiplaque effects of these Mexican plants, they could still be useful as an alternative treatment of several periodontal diseases or as anticariogenic agents. However, the number of studies supporting their uses and effects remains insufficient.</P><P><B>Discussion and conclusion:</B> It is important for the health of consumers to scientifically demonstrate the real effects of natural medicine, as well as clarify and establish their possible therapeutic applications. Through this bibliographical revision, we found papers that testify or refute their ancestral uses, and conclude that the use of plants to treat oral conditions or to add to the dental pharmacological arsenal should be based on experimental studies verifying their suitability for dental treatments.</P>
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Kim, Namkwon,Martí,nez, Cindy Cruz,Jang, Dae Sik,Lee, Jong Kil,Oh, Myung Sook Elsevier 2019 Biomedicine & pharmacotherapy Vol.111 No.-
<P><B>Abstract</B></P> <P>Abnormal inflammatory response in the central nervous system plays a critical role in various neurological disorders such as Parkinson’s disease, Alzheimer’s disease and Huntington’s disease. Therefore, modulation of abnormal neuroinflammation is thought to be a promising therapeutic strategy for these diseases. Based on this idea, we focused on finding a potential candidate material that would regulate excessive neuroinflammation. <I>Iresine celosia</I> has long been used as a traditional Mexican medicine to treat fever and oral disorders. In the present study, we evaluated the anti-neuroinflammatory effects of <I>Iresine celosia</I> extract (ICE) in lipopolysaccharide (LPS)-stimulated BV2 microglia cells and mice models. In BV2 microglia cells, ICE markedly inhibited production of nitric oxide and proinflammatory cytokines such as tumor necrosis factor-α, interleukin-1β, and interleukin-6 without causing cytotoxicity. ICE also ameliorated translocation of nuclear factor-κB from cytosol to nucleus by LPS. Moreover, ICE attenuated behavioral disturbances by inhibiting activation of microglia and astrocytes in LPS-treated mice. Collectively, these data indicate that ICE is a potential therapeutic agent for treating inflammation-related diseases.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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