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RISS 인기검색어
- 검색키워드
- 저자 : Connie M. Weaver (검색결과 2 건)
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New Era Nutrition and Food Research is Leading Us Beyond Essential Nutrients
Connie M. Weaver 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Dietary guidance and nutrient recommendations have traditionally been based on meeting essential nutrient needs to prevent nutrient deficiencies. The explosion of interest in bioactive constituents and functional foods for promoting health and resiliency to prevent chronic disease is raising questions about what kind of research is needed to create a rigorous evidence based for setting food guidance policy and what the process should be for developing the policies. A chronic disease risk reduction category was developed and applied first to sodium and potassium. A Dietary Reference Intake-type proposed process for bioactive foods and beverages was recently developed. Best practices for designing and conducting human nutrition clinical trials were published in a series of articles in Advances in Nutrition in 2020 and 2021. Key elements will be highlighted from our dose response randomized, controlled trial of blueberries and bone health in postmenopausal women that will be featured in Frontiers in Nutrition. New tools for identifying biomarkers of exposure and outcome measures are launching an era of personalized nutrition.
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Elsa M. Janle,Mary Ann Lila,Michael Grannan,Lauren Wood,Aine Higgins,Gad G. Yousef,Randy B. Rogers,Helen Kim,George S. Jackson,Lap Ho,Connie M. Weaver 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.4
Grape polyphenols confer potential health benefits, including prevention of neurodegenerative diseases. To determine the absorption and tissue distribution of the complex grape polyphenol mixture, 14C-labeled polyphenols were biosynthesized by grape cell suspension cultures, during co-incubation with radioisotopically labeled sucrose, and fractionated into polyphenolic subfractions. The pharmacokinetics and distribution of grape polyphenols into blood, brain, and peripheral interstitial fluid were determined by tracking the 14C label. The blood peak 14C concentration of the fractions ranged from 15 minutes to 4 hours. Absorption and tissue distribution varied greatly between fractions. Concentrations in interstitial fluid were lower than in blood. The amount of residual label in the brain at 24 hours ranged from 0.1% to 1.7% of the dose, depending on the fraction. 14C label found in the brain tissue and brain microdialysate indicated that grape polyphenols or their metabolites are able to cross the blood–brain barrier. Using 14C-labeled plant polyphenols it is possible to track the compounds or their metabolic products into any tissue and determine distribution patterns in spite of low concentrations. A central question regarding the potential role of dietary polyphenolics in neurodegenerative research is whether they are bioavailable in the brain. Our observations indicate that some grape-derived polyphenolics do reach the brain, which suggests their potential value for applications in neurodegenerative disorders.
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