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- 저자 : Chunni Zhang (검색결과 2 건)
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Lee, Hwa Jeong,Zhang, Yun,Zhu, Chunni,Duff, Karen,Pardridge, William M. 梨花女子大學校 藥學硏究所 2002 藥學硏究論文集 Vol.- No.11
Aβ^1-40 is a potential peptide radiopharmaceuticalthat coilid be used to image the brain Aβ amyloid of Alaheimerdisease in vivo, should this peptide be made transportablethrough the blood-brain barier in vivo. The blood-brain barriertransport of[^125I]-Aβ^1-40 in a transgenic mouse model wasenabled by conjugation to the rat 8D3 monoclonal antibody tothe mouse transferrin receptor. The Aβ^1-40_8D3 conjugate is abifunctional molecule that binds the blood-brain barrier TfRand unuergoes transport into brain and binds the Aβ amyloidpiaques of AIzheimer disease. App^sw/Psenl double-transgenicand littermate control mice were administered either unconju-gated Aβ^1-40 or the Aβ^1-40_8D3 conjugate intravenously, andbrain scans were obtained 6 hours later. Immunocytochemical analysis showed abundant Aβ immunoreactive plaques in thebrains of the App^sw/Psenl transgenic mice and there was aselective retention of radioactivity in the brains of these mice at6 hours after intravenous administration of the conjugate. Incontrast, there was no selective sequestration either of the con-jugate in control littermate mouse brain or of unconjugatedAβ in transgenic mouse brain. In conclusion, the resultsshow that it is possible to image the Aβ amyloid burden in thebrain in vivo with an amyloid imaging agent, provided themolecule is conjugated to a blood-brain barrier drug-targetingsystem.
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Long Ma,Wu Dai,Xianchun Li,Yalin Zhang,Chunni Zhang 한국응용곤충학회 2015 Journal of Asia-Pacific Entomology Vol.18 No.2
Trehalase plays a significant role in various physiological processes in insects. In this study, we cloned and characterized a soluble trehalase gene (HaTreh-1) and a membrane-bound trehalase gene (HaTreh-2) from Helicoverpa armigera, a serious polyphagous pest of crops. HaTreh-1 contained an open reading frame of 1716 bp that encodes a protein of 572 amino acids. HaTreh-2 has an open reading frame of 1938 bp, encoding a protein of 646 amino acids. Sequence alignment and phylogenetic analysis of the two putative proteins revealed that HaTreh-1 and HaTreh-2 belong to soluble and membrane-bound trehalase groups, respectively. Quantitative real-time PCR (qPCR) analyses of the spatiotemporal expression pattern of HaTreh in H. armigera revealed that HaTreh-1 was expressed mainly in the midgut, with lower expression in the integument and head, Malpighian tubules, trachea, and fat body. The expression levels of HaTreh-2 were detected in all 6 tissues, and HaTreh-2 was mainly expressed in the midgut and head. Expression of HaTreh-1 was higher throughout the larval stages, but lower on days 1 and 2 of the pupal stage. Expression of HaTreh-2 was higher during the 4th- and 5th-instar larval stages. Taken together, these results suggest that HaTreh-1 and HaTreh-2 have different functions in various developmental stages and tissues.
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