http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Chunhui Du (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
5-Fluorouracil delivery from a novel three-dimensional micro-device: in vitro and in vivo evaluation
Na Zheng,Mingyao Zhou,Chunhui Du,Sicen Wang,Wen Lu 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.12
A novel three-dimensional biodegradablemicro-device using microelectromechanical systems technologywas developed for implantable controlled drugdelivery. In order to evaluate the effect of monomercomposition and molecular weight of poly(lactic-coglycolicacid) (PLGA) on the drug release, three 5-Fluorouracilloaded micro-devices, made of 50/50, 27 kDa;50/50, 40 kDa and 75/25 27 kDa PLGA, were preparedand characterized by in vitro and in vivo methods. Thein vitro drug release from three micro-devices followedzero-order kinetics, and PLGA micro-device with thehigher molecular weight and lactide/glycolide ratio tendedto a longer sustained release period. The in vivo releaseresults agreed with the in vitro results and drug releasein vivo was faster than that in vitro for each of microdevices. And three micro-devices showed different tumorinhibition effect in the tumor bearing mice. In addition, theSEM and weight loss experiments showed that PLGAmicro-devices with lower molecular weight and lactide/glycolide ratio had faster degradation. These data providedthe information for the optimization of the novel threedimensionalbiodegradable micro-device to obtain moresuitable systems for controlled release and to meet releaserequirements of different drugs.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
