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        Crosslinked Ionic Alginate and Cellulose-based Hydrogels for Photoresponsive Drug Release Systems

        Fang Zhou,Shaohua Wu,Chris Rader,Jianwei Ma,Shaojuan Chen,Xiaoyan Yuan,E Johan Foster 한국섬유공학회 2020 Fibers and polymers Vol.21 No.1

        In this work, photosensitive alginate and cellulose-based hydrogels with interpenetrating polymer networks weresuccessfully prepared from alginate, TEMPO-oxidized cellulose nanofibers (TEMPO-CNFs) and polyacrylamide,crosslinked by both Fe3+ and N,N'-methylenebis-acrylamide. The obtained hydrogels showed a clear relationship between themechanical properties and the content of the TEMPO-CNFs. The results indicated that the mechanical properties ofcrosslinked hydrogels were enhanced with the mass ratio of TEMPO-CNFs and alginate increased from 1/2 to 2. Moreover,the crosslinked ionic alginate and cellulose-based hydrogels with various TEMPO-CNFs contents exhibited aninterconnected porous morphology with an average pore size of ca. 130 μm, and demonstrated an increased cumulativerelease amount of BSA drugs under the ultraviolet irradiation. This study demonstrated that the as-prepared photoresponsivehydrogels would have a potential application as local drug release systems for wound dressings.

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