http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Time Course Effect of R-Alpha-Lipoic Acid on Cellular Metabolomics in Cultured Hepatoma Cells
Naoko Ikuta,Keita Chikamoto,Yuya Asano,Yoshiaki Yasui,Haruka Yokokawa,Keiji Terao,Gerald Rimbach,Seiichi Matsugo 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.3
Alpha-lipoic acid (LA) is a powerful antioxidant. LA has two enantiomers, R(+)-LA (R-LA) and S(−)-LA (S-LA). Of these, R-LA is naturally occurring and an essential cofactor in energy metabolism. R-LA treatment has been reported to affect glucose metabolism in rat hepatoma cells. This study analyzed the time course of metabolite levels in LA-treated cultured H4IIEC3 rat hepatoma cells, including a specific evaluation of the effect of R-LA and the enantioselectivity of LA. Principal component analysis showed that this experiment was well designed to observe enantioselectivity. R-LA treatment was found to inhibit the glycolysis and Thr-Gly-Ser pathways, as well as lactic acid production, leading to the inhibition of gluconeogenesis in starved H4IIEC3 cells. This study may provide mechanistic insight into how R-LA induces apoptosis in hepatoma cells.
Revisiting ENSO/Indian Ocean Dipole phase relationships : REVISITING ENSO/IOD PHASE RELATIONSHIPS
Stuecker, Malte F.,Timmermann, Axel,Jin, Fei-Fei,Chikamoto, Yoshimitsu,Zhang, Wenjun,Wittenberg, Andrew T.,Widiasih, Esther,Zhao, Sen American Geophysical Union 2017 Geophysical research letters Vol.44 No.5
Pantropical climate interactions
Cai, Wenju,Wu, Lixin,Lengaigne, Matthieu,Li, Tim,McGregor, Shayne,Kug, Jong-Seong,Yu, Jin-Yi,Stuecker, Malte F.,Santoso, Agus,Li, Xichen,Ham, Yoo-Geun,Chikamoto, Yoshimitsu,Ng, Benjamin,McPhaden, Mich American Association for the Advancement of Scienc 2019 Science Vol.363 No.6430
<P><B>Tropical interconnections</B></P><P>The El Niño–Southern Oscillation, which originates in the tropical Pacific, affects the rest of the world's tropics by perturbing global atmospheric circulation. Less appreciated than this influence is how the tropical Atlantic and Indian Oceans affect the Pacific. Cai <I>et al.</I> review what we know about these pantropical interactions, discuss possible ways of improving predictions of current climate variability, and consider how projecting future climate under different anthropogenic forcing scenarios may be improved. They argue that making progress in this field will require sustained global climate observations, climate model improvements, and theoretical advances.</P><P><I>Science</I>, this issue p. eaav4236</P><P>The El Niño–Southern Oscillation (ENSO), which originates in the Pacific, is the strongest and most well-known mode of tropical climate variability. Its reach is global, and it can force climate variations of the tropical Atlantic and Indian Oceans by perturbing the global atmospheric circulation. Less appreciated is how the tropical Atlantic and Indian Oceans affect the Pacific. Especially noteworthy is the multidecadal Atlantic warming that began in the late 1990s, because recent research suggests that it has influenced Indo-Pacific climate, the character of the ENSO cycle, and the hiatus in global surface warming. Discovery of these pantropical interactions provides a pathway forward for improving predictions of climate variability in the current climate and for refining projections of future climate under different anthropogenic forcing scenarios.</P>