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- 저자 : Chen Zipeng (검색결과 4 건)
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Zipeng Gong,Ying Chen,Ruijie Zhang,Qing Yang,Yajie Wang,Yan Guo,Bingbing Zhou,Xiaogang Weng,Xuchen Liu,Yujie Li,Xiaoxin Zhu,Yu Dong 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.10
Berberine is one of active alkaloids from Rhizomacoptidis in traditional Chinese medicine. The pharmacokineticsof berberine in rat plasma were compared betweennormal and chronic visceral hypersensitivity irritable bowelsyndrome rats (CVH-IBS) established by mechanical colonirritation using angioplasty balloons for 2 weeks after oraladministration of berberine hydrochloride (25 mg/kg) withthe equivalent dose of 22 mg/kg for berberine according tobody weight. Immunohistochemical analysis of c-fos andmyosin light chain kinase (MLCK) and immunofluorescenceanalysis of MLCK in rat colon were conducted. Quantificationof berberine in rat plasma was achieved by using a sensitiveand rapidUPLC-MS/MSmethod. Plasma samples werecollected at 15 different points in time and the pharmacokineticparameters were analyzed by WinNonlin software. Thegreat different pharmacokinetic behavior of berberine wasobserved between normal and CVH-IBS model rats. Compared with normal group, T1/2 and AUC(0–t) of berberinein the model group were significantly increased, respectively(573.21 ± 127.53 vs 948.22 ± 388.57 min; 8,657.19 ±1,562.54 vs 11,415.12 ± 1,670.72 min.ng/ml). Cl/F of berberinein the model group significantly decreased, respectively(13.89 ± 1.69 vs 9.19 ± 2.91 L/h/kg). Additionally,the expressions of c-fos and MLCK in model group werehigher than those in normal group. The pharmacokinetic behaviorof berberine was significantly altered in CVH-IBSpathological conditions, which indicated the dosage modificationof berberine hydrochloride in CVH-IBS were necessary. Especially, improved exposure to berberine in ratplasma inCVH-IBSmodel rats was attributed to increased theexpression of MLCK.
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Zhang Zipeng,Xu Nan,Chen Hong,Wang Zhenfeng,Li Fei,Wang Xinyu 한국자동차공학회 2021 International journal of automotive technology Vol.22 No.6
This paper presents a novel model-based observer algorithm to address issues associated with nonlinear suspension system state estimation using interacting multiple model unscented Kalman Filters (IMMUKF) under various road excitation. Due to the fact that practical working condition is complex for the suspension system, e.g. additional load. Meanwhile, the changed sprung mass parameter will induce model changed of suspension system, and it can lead to state transition between various models. To tackle the mentioned issue, the models of road profile and suspension system are first established to describe the nonlinear suspension dynamics. Then, considering the variation of sprung mass under various movement conditions, an unscented Kalman Filter (UKF) algorithm is proposed to identify the sprung mass. Based on the interacting multiple model (IMM) and Markov Chain Monte Carlo (MCMC) theory, a novel IMMUKF observer is developed to estimate the movement state of suspension system. The stability conditions for the proposed observer is calculated using the stochastic stability theory. Finally, simulations and validations are performed on a quarter vehicle suspension system under various ISO road excitations, to validate the UKF and IMMUKF algorithms for acquiring suspension system states, and results illustrate that the maximum root mean square error of state estimation for the proposed algorithm is less than 7.5 %.
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Lv Tiantong,Chen Zipeng,Wang Dengfeng,Du Xuejing 한국CDE학회 2024 Journal of computational design and engineering Vol.11 No.1
Combined application of steel, aluminum, and carbon fiber reinforcement plastic (CFRP) is the main direction of future lightweight body development. However, the anisotropy and additional lamination design variables of CFRP parts pose significant challenges for the development of multi-material bodies. This study establishes a parametric design method for the variable-thickness lamination scheme based on non-uniform rational B-splines, it can be coupled with existing parametric design methods for structural shapes to formulate a complete parametric design and modeling of CFRP components. On this basis, a homogenized intermediate material property is derived from classic laminate theory by introducing lamination assumptions, it enables a stepwise multi-material body optimization method to solve the challenge that components’ material design variables switching between CFRP and alloy will introduce/eliminate lamination design variables iteratively, posing a great optimization convergence difficulty. The proposed parametric modeling method for CFRP components was validated by experimental tests of a fabricated roof beam, and the proposed optimization method was applied to a vehicle body, achieving 15.9%, 23.9%, 18.6%, and 12.2% increase in bending and torsional stiffness and modal frequencies; 20.2%, 9.3%, and 12.7% reduction of weight and peak acceleration in frontal and side collisions. This study enables the forward design of multi-material bodies compatible with CFRP parts.
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