Observation of multi-channel non-local transport in J-TEXT plasmas

Shi, Yuejiang,Chen, Zhongyong,Yang, Zhoujun,Shi, Peng,Zhao, Kaijun,Diamond, Patrick H.,Kwon, JaeMin,Yan, Wei,Zhou, Hao,Pan, Xiaoming,Cheng, Zhifeng,Chen, Zhiping,Yang, SeongMoo,Zhang, Chi,Li, Da,Dong, IOP 2018 Nuclear fusion. Fusion nucléaire. &n.Illiga Vol.58 No.4

<P>In cold pulse experiments in J-TEXT, not only are rapid electron temperature increases in the core observed, but also steep rises in the inner density are found. Moreover, some evidence of acceleration of the core toroidal rotation is also observed during the non-local transport process of electron temperature. These new findings of cold pulse experiments in J-TEXT suggest that turbulence spreading is a possible mechanism for the non-local transport dynamics.</P>

Clinicopathologic Characteristics and Prognoses for Multicentric Occurrence and Intrahepatic Metastasis in Synchronous Multinodular Hepatocellular Carcinoma Patients

Li, Shi-Lai,Su, Ming,Peng, Tao,Xiao, Kai-Yin,Shang, Li-Ming,Xu, Bang-Hao,Su, Zhi-Xiong,Ye, Xin-Ping,Peng, Ning,Qin, Quan-Lin,Chen, De-Feng,Chen, Jie,Li, Le-Qun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1

Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and the outcomes for patients are still poor. It is important to determine the original type of synchronous multinodular HCC for preoperative assessment and the choice of treatment therapy as well as for the prediction of prognosis after treatment. Aims: To analyze clinicopathologic characteristics and prognoses in patients with multicentric occurrence (MO) and intrahepatic metastasis (IM) of synchronous multinodular hepatocellular carcinoma (HCC). Methods: The study group comprised 42 multinodular HCC patients with a total of 112 nodules. The control group comprised 20 HCC patients with 16 single nodular HCC cases and 4 HCC cases with a portal vein tumor emboli. The mitochondrial DNA (mtDNA) D-loop region was sequenced, and the patients of the study group were categorized as MO or IM based on the sequence variations. Univariate and multivariate analyses were used to determine the important clinicopathologic characteristics in the two groups. Results: In the study group, 20 cases were categorized as MO, and 22 as IM, whereas all 20 cases in the control group were characterized as IM. Several factors significantly differed between the IM and MO patients, including hepatitis B e antigen (HBeAg), cumulative tumor size, tumor nodule location, cirrhosis, portal vein and/or microvascular tumor embolus and the histological grade of the primary nodule. Multivariate analysis further demonstrated that cirrhosis and portal vein and/or microvascular tumor thrombus were independent factors differentiating between IM and MO patients. The tumor-free survival time of the MO subjects was significantly longer than that of the IM subjects ($25.7{\pm}4.8$ months vs. $8.9{\pm}3.1$ months, p=0.017). Similarly, the overall survival time of the MO subjects was longer ($31.6{\pm}5.3$ months vs. $15.4{\pm}3.4$ months, p=0.024). The multivariate analysis further demonstrated that the original type (p=0.035) and Child-Pugh grade (p<0.001) were independent predictors of tumor-free survival time. Cirrhosis (p=0.011), original type (p=0.034) and Child-Pugh grade (p<0.001) were independent predictors of overall survival time. Conclusions: HBeAg, cumulative tumor size, tumor nodule location, cirrhosis, portal vein and/or microvascular tumor embolus and histological grade of the primary nodule are important factors for differentiating IM and MO. MO HCC patients might have a favorable outcome compared with IM patients.

A novel pathogenic deletion in ISPD causes Walker-Warburg syndrome in a Chinese family

Shi Yuting,Fu Yimei,Tao Zhouteng,Yong Wenjing,Peng Huirong,Jian Wenyang,Chen Gang,Guo Manhui,Zhao Yanhua,Yao Ruojin,Guo Dewei 한국유전학회 2023 Genes & Genomics Vol.45 No.3

Background Walker-Warburg syndrome (WWS) is a genetically heterogeneous disease that often presents with complex brain and eye malformations and congenital muscular dystrophy. Mutations of the ISPD gene have been identified as one of the most frequent causes of WWS. Objective The current study aimed to identify the cause of severe congenital hydrocephalus and brain dysplasia in our subject. Methods Genomic DNA was extracted from the fetus's umbilical cord blood and peripheral venous blood of the parents. The genetic analysis included whole-exome sequencing and qPCR. Additionally, in silico analysis and cellular experiments were performed. Results We identified a novel homozygous deletion of exons 7 to 9 in the ISPD gene of the fetus with WWS. In silico analysis revealed a defective domain structure in the C-terminus domain of the ISPD. Analysis of the electrostatic potential energy showed the formation of a new binding pocket formation on the surface of the mutant ISPD gene (ISPD-del ex7-9). Cellular study of the mutant ISPD revealed a significant change in its cellular localization, with the ISPD-del ex7-9 protein translocating from the cytoplasm to the nucleus compared to wild-type ISPD, which is mostly present in the cytoplasm. Conclusion The present study expands the mutational spectrum of WWS caused by ISPD mutations. Importantly, our work suggests that whole-exome sequencing could be considered as a diagnostic option for fetuses with congenital hydrocephalus and brain malformations when karyotype or chromosomal microarray analysis fails to provide a definitive diagnosis.

Exact Solution of Coupled Heat and Mass Transfer with One Discrete Sublimation Moving Interface and One Desorption Mushy Zone in a Cylindrically Symmetrical Porous Space

Shi Wen Peng,Guo Qian Chen 대한기계학회 1993 International Symposium on Transport Phenomena in Vol.3 No.1

Cyano-substituted benzochalcogenadiazole-based polymer semiconductors for balanced ambipolar organic thin-film transistors

Shi, Shengbin,Wang, Hang,Chen, Peng,Uddin, Mohammad Afsar,Wang, Yuxi,Tang, Yumin,Guo, Han,Cheng, Xing,Zhang, Shiming,Woo, Han Young,Guo, Xugang The Royal Society of Chemistry 2018 Polymer chemistry Vol.9 No.28

<P>Due to their high-lying lowest unoccupied molecular orbitals (LUMOs), π-conjugated polymers based on benzothiadiazole and its derivatives typically are p-type. We report here the successful development of two narrow bandgap, ambipolar donor-acceptor copolymers, PDCNBT2T and PDCNBSe2T, which are based on new cyano-substituted strong electron acceptors, 4,7-dibromo-5,6-dicyano-2,1,3-benzothiadiazole (DCNBT) and 4,7-dibromo-5,6-dicyano-2,1,3-benzoselenadiazole (DCNBSe), respectively. Compared to their polymer analogues with fluorine substituents, the LUMO was lowered by a big margin of <I>ca.</I> 0.6 eV and the bandgap was reduced by 0.2-0.3 eV for the cyano-substituted polymers. Therefore, the cyano-substituted benzothiadiazole polymers showed very low-lying LUMO levels of <I>ca.</I> 4.3 eV. Benefiting from their narrow bandgaps of 1.1-1.2 eV and appropriately positioned LUMO levels, both polymers exhibit well balanced ambipolar transport characteristics in organic thin-film transistors, which differ from the p-type dominating transport properties of their fluorinated polymer analogues. A balanced hole/electron mobility of 0.59/0.47 cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP> was achieved for polymer PDCNBT2T, and a reduced hole/electron mobility of 0.018/0.014 cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP> was observed for the benzoselenadiazole-based PDCNBSe2T due to its lower crystallinity. These results show that the electron mobility can be enhanced by approximately two orders <I>versus</I> the electron mobility of the previously reported 4,7-di(thiophen-2-yl)-5,6-dicyano-2,1,3-benzothiadiazole-based polymer. This improvement was achieved by using the new acceptor units without additional electron-rich thiophene flanks, which allow a higher degree of freedom in selecting the donor co-unit and more effective tuning of energy levels of frontier molecular orbitals.</P>

Head-to-Head Linked Dialkylbifuran-Based Polymer Semiconductors for High-Performance Organic Thin-Film Transistors with Tunable Charge Carrier Polarity

Shi, Shengbin,Wang, Hang,Uddin, Mohammad Afsar,Yang, Kun,Su, Mengyao,Bianchi, Luca,Chen, Peng,Cheng, Xing,Guo, Han,Zhang, Shiming,Woo, Han Young,Guo, Xugang American Chemical Society 2019 Chemistry of materials Vol.31 No.5

<P>A planar backbone conformation is essential for enabling polymer semiconductors with high charge carrier mobility in organic thin-film transistors. Benefiting from the smaller van der Waals radius of the O atom in furan (versus the S atom in thiophene), alkylated furan exerts a reduced steric hindrance on neighboring arene, and it was found that the head-to-head (HH)-linked 3,3′-dialkyl-2,2′-bifuran (<B>BFR</B>) can attain a high degree of backbone planarity. Hence, <B>BFR</B> should be a promising building block for constructing polymer semiconductors with a planar backbone conformation and hold distinctive advantages over a dialkylbithiophene-based analogue, which is typically highly twisted. The alkyl chains on the 3 and 3′ positions offer good solubility to the resulting polymers, which in combination with its planar backbone yields an improved molecular design window for developing high-performance polymer semiconductors, particularly those with a simple molecular structure and based on the acceptor co-unit without any solubilizing chains. When incorporated into polymer semiconductors, remarkably high hole and electron mobilities of 1.50 and 0.31 cm<SUP>2</SUP> V<SUP>-1</SUP> s<SUP>-1</SUP> are obtained for <B>BFR</B>-based polymers <B>FBFR-BO</B> and <B>CNBFR-C18</B> containing fluorinated and cyano-functionalized benzothiadiazole as the acceptor co-unit, respectively. Such mobilities are the highest values for HH-linked polymers and also among the best for furan-containing polymers. The results demonstrate that HH-linked dialkylbifuran is a highly promising building block for constructing organic and polymeric semiconductors, and this new approach by incorporating HH <B>BFR</B> offers several distinctive advantages for developing high-performance polymer semiconductors, including effective optoelectronic property tuning using a minimal number of aromatic rings, reduced structural complexity, facile material synthesis, good material solubility, and enriching the material library. In addition, the study offers important guidelines for future development of furan-based polymers and head-to-head linkage containing organic semiconductors.</P> [FIG OMISSION]</BR>

Role of miR-511 in the Regulation of OATP1B1 Expression by Free Fatty Acid

Peng, Jin Fu,Liu, Li,Guo, Cheng Xian,Liu, Shi Kun,Chen, Xiao Ping,Huang, Li Hua,Xiang, Hong,Huang, Zhi Jun,Yuan, Hong,Yang, Guo Ping The Korean Society of Applied Pharmacology 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.5

MicroRNAs (miRNAs) are a family of non-coding RNA that are able to adjust the expression of many proteins, including ATP-binding cassette transporter and organic cation transporter. We sought to evaluate the effect of miR-511 on the regulation of OATP1B1 expression by free fatty acids. When using free fatty acids to stimulate Chang liver cells, we found that the expression of miR-511 increased significantly while the expression of OATP1B1 decreased. We also proved that SLCO1B1 is the target gene of miR-511 with a bioinformatics analysis and using the dual luciferase reporter assay. Furthermore, the expressions of SLCO1B1 and OATP1B1 decreased if transfecting Chang liver cells with miR-511, but did not increase when transfecting the inhibitors of miR-511 into steatosis cells. Our study indicates that miR-511 may play an important role in the regulation of OATP1B1 expression by free fatty acids.

Relationship Between GSTT1 Gene Polymorphism and Hepatocellular Carcinoma in Patients from China

Chen, Jie,Ma, Liang,Peng, Ning-Fu,Wang, Shi-Jun,Li, Le-Qun Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

Objective: The results from studies on associations of the glutathione S-transferase T1 (GSTT1) gene polymorphism and hepatocellular carcinoma (HCC) risk in Chinese populations are still conflicting. This meta-analysis was performed to evaluate the relationship in detail. Methods: Eligible reports were recruited into this meta-analysis from the databases of PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database). Results were expressed with odds ratios (OR) for dichotomous data, and 95% confidence intervals (CI) were also calculated. Results: Eighteen investigations were identified for the analysis of association between polymorphic deletion of GSTT1 and HCC, consisting of 2,693 patients with HCC and 4,696 controls. Null genotype of GSTT1 was associated with HCC susceptibility in Chinese (OR=1.53, 95%CI: 1.28-1.82; P<0.00001). Conclusion: The GSTT1 null genotype is associated with HCC susceptibility in Chinese.

New Stochastic Robust Stability Criteria for Time-Varying Delay Neutral System with Markovian Jump Parameters

Jing Chen,Ji-Qing Qiu,Peng Shi,Hong-Jiu Yang 제어·로봇·시스템학회 2010 International Journal of Control, Automation, and Vol.8 No.2

In this paper, the problem of stochastic robust stability of time-varying delay neutral system with Markovian jump parameters is investigated. The jumping parameters are considered as a continuous-time, continuous state Markov process. Based on the Lyapunov-Krasovskii functional approach, a new delay-dependent stochastic stability criteria is presented in terms of LMIs. A numerical example is given to illustrate the effectiveness of the developed method.

論文 : 《黃帝內經》"洞泄"略探

주붕거 ( Peng Ju Zhu ),진사옥 ( Shi Yu Chen ),곡봉 ( Feng Gu ) 대한한의학원전학회 ( 구 대한원전의사학회 ) 2009 대한한의학원전학회지 Vol.22 No.4

According to the original texts in 『Hwangjenaegyeong(黃帝內經)』, it`s considered that the Chinese character Tong(洞) in the word of Tongseol(洞泄) should be understood as fast[疾] or rapid[速], and the main symptom of Tongseol should be diarrhea of indigested food soon after a meal. Through comparing Tongseol with Dongpung(동風) in Historical Records, we can draw the conclusions as following. Firstly, the ancient physicians attached great importance to the role of wind in the pathogenesis of diarrhea, Secondly, perhaps the ancient physicians had these ideas of "wind is rapid" and "strong wind can bring shaken" as well as "wind is related to the liver closely" already in the early Western Han Dynasty. Thirdly, the rich materials about the relationship between wind and diarrhea in 『Hwangjenaegyeong(黃帝內經)』 should be considered as the successor to the excellent thinking of their predecessors.