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Wu Dongzhe,Shen Yulin,Qu Chaoyi,Huang Peng,Geng Xue,Zhang Jianhong,Rao Zhijian,Wei Qiangman,Liu Shijie,Zhao Jiexiu 한국역학회 2024 Epidemiology and Health Vol.46 No.-
OBJECTIVES In light of the rise in the global aging population, this study investigated the potential of the oxidative balance score (OBS) as an indicator of phenotypic age acceleration (PhenoAgeAccel) to better understand and potentially slow down aging. METHODS Utilizing data from the National Health and Nutrition Examination Survey collected between 2001 and 2010, including 13,142 United States adults (48.7% female and 51.2% male) aged 20 and above, OBS and PhenoAgeAccel were calculated. Weighted generalized linear regression models were employed to explore the associations between OBS and PhenoAgeAccel, including a sex-specific analysis. RESULTS The OBS demonstrated significant variability across various demographic and health-related factors. There was a clear negative correlation observed between the higher OBS quartiles and PhenoAgeAccel, which presented sex-specific results: the negative association between OBS and PhenoAgeAccel was more pronounced in male than in female. An analysis using restricted cubic splines revealed no significant non-linear relationships. Interaction effects were noted solely in the context of sex and hyperlipidemia. CONCLUSIONS A higher OBS was significantly associated with a slower aging process, as measured by lower PhenoAgeAccel. These findings underscore the importance of OBS as a biomarker in the study of aging and point to sex and hyperlipidemia as variables that may affect this association. Additional research is required to confirm these results and to investigate the biological underpinnings of this relationship.
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Yonghui Zhou,Hu Sun,Anhai Li,Minghang Lv,Chaoyi Xue,Jun Zhao 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.7
The Johnson-Cook (JC) constitutive model was utilized to simulate the processing of Al-Si piston alloy ZL109 to obtain the optimal finishing parameters in polycrystalline diamond (PCD) tool, and studied the machining quality of ordinary-turning under the optimized cutting parameters. PCD is brittle, so it is difficult to manufacture orthogonal blades and is easy to break and high cost. We have adopted ordinary-turning quality to verify simulation results. Effect of cutting parameters on residual stress, cutting force and temperature was investigated through simulation, meanwhile, effect of cutting parameters on surface roughness and residual stress was analyzed by experiments. It indicates the verification method is practicable, and residual stress, cutting force and temperature are the smallest in simulation, and the experimental values of surface roughness and residual stress are also the smallest under the optimal cutting parameters, which can guide the cutting parameters selection to obtain higher machining quality.
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