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Inhibition of Phthalic Anhydride-Induced Skin Inflammation in IL-4 Knock-out Mice
Changjoon Bae,Miran Kim,Chuelkyu Kim,Byoungguk Kim,Sunbo Shim,Suhae Lee,Jisoon Sin,Jongmin Woo,Nonghoon Choe,Zaeyoung Ryoo,Changkyu Lee,Kabryong Chae 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.3
Atopic dermatitis and asthma are common chronic inflammatory diseases. A pivotal role of IL-4 in airway inflammation has been elucidated by studying mice in which IL-4 was genetically disrupted. However, there have been no trials to examine the effect of IL-4 dysfunction on skin inflammation. Thus, the aim of this study was to investigate the role of IL-4 in skin inflammation using IL-4<SUP>-/-</SUP> mice. To induce skin inflammation, a 15% phthalic anhydride solution was repeatedly applied to the dorsal surfaces of the ears of both IL-4<SUP>-/-</SUP> and BALB/c mice for 5 weeks. After treatment, skin inflammation-related factors were detected in the ear tissue, lymph nodes, spleens, and sera of the mice. Ear thicknesses and weights of the auricular lymph nodes, indicating the degree of skin inflammation, were significantly smaller in IL-4<SUP>-/-</SUP> mice than in BALB/c mice. Immunoglobulin E concentrations in sera were also significantly lower in IL-4<SUP>-/-</SUP> mice. In cytokine secretion profiles, expression levels of inflammation-inducing cytokines and chemokines, such as IL-6, IL-10, IL-13, KC, MCP-1 and VEGF were lower in IL-4<SUP>-/-</SUP> mice than in BALB/c. These findings suggest that knock-out of IL-4 relieves allergen-induced skin inflammation. Thus, the modulation of IL-4 expression may provide important insights into therapeutic targets of chronic skin inflammatory diseases, such as atopic dermatitis.
Park, Moon-Baik,Ko, Eunjung,Ahn, Changjoon,Choi, Hyun,Rho, Samwoong,Shin, Min-Kyu,Hong, Moo-Chang,Min, Byung-Il,Bae, Hyunsu WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-
Effects of electroacupuncturc (EA) on Th1/Th2 cell response were investigated in BALB/c mice immunized intraperitoneally with 2,4-dinitrophenylated keyhole limpet protein (DNP-KLH). Successive electroacupuncture stimulation on the ST36 acupoint was performed just after immunization. Serum levels of antigen-specific lgE and total lgE were significantly decreased compared with non-acupunctured controls. Production of the Th2-specific cytokines IL-4 and IL-13 in the anti-CD3 mAb-activated splenocytes was significantly suppressed in ST36 electroacupunctured mice compared with non-acupunctured mice. These results imply that successive electroacupuncture on ST36 can decrease the serum level of antigen-specific lgE and total lgE by suppression of the Th2 lineage development.