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XiaoWei Song,Yong Ji Yang,Ya Feng Shen,Mi Cao,QingNing Yuan,Ying Tang,Changhai Lei 한국통합생물학회 2014 Animal cells and systems Vol.18 No.3
Acute myocardial infarction remains one of the leading causes of death and disability worldwide. Themechanisms underlying myocardial infarction involve a complex of signaling molecules, such as tumornecrosis factor α (TNFα), interleukin-6 (IL6), C-Myc, atria natriuretic peptide (ANP), superoxide dismutase1 (SOD1), and so on. The aim of this study is to understand the time-dependent expressional pattern of theseearly responsible genes following acute myocardial ischemia established by left anterior descending (LAD)coronary artery ligation. After LAD ligation, a collection of genes was detected using real-time polymerasechain reaction (PCR). The expression of inflammation-related genes, such as TNFα and IL6, was immediatelyupregulated at 2 h, reached to the highest point at 12 h, and then decreased to nearly basis level at 24 h afterligation, suggesting inflammation appeared and disappeared rapidly after acute ischemia. C-Myc, an importanttranscription factor, was significantly upregulated at 2 h, and thereafter persisted at high level to 24 h. Thesecretary peptide, ANP, was consistently upregulated from 2 to 24 h, reached to 40-folds at 24 h. The calciumregulatedgene, FK506-binding protein 12.6, was not significantly altered after ischemia. SOD1 was not alteredat the first 4 h, and began to downregulate at 12 and 24 h. These results indicate that several genes weredynamically and transiently regulated after acute myocardial infarction (AMI) in a time-dependent pattern,suggesting that there is an immediate molecular response to acute myocardial ischemia, which might provideus a new insight to understand molecular mechanisms of AMI.