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RISS 인기검색어
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- 저자 : Chandrakant Ankolekar (검색결과 3 건)
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Chandrakant Ankolekar,Trisha Terry,Kevin Johnson,David Johnson,Ana Christina Lopez Barbosa,Kalidas Shetty 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.10
Tea (Camellia sinensis) has well-known health benefits, which are attributed to its polyphenolic metabolites. This research explored the potential of regular tea consumption and influence of extraction time typically used in daily consumption of tea, as a therapeutic dietary support for potential management of early stage type 2 diabetes using in vitro assay models. Extraction times of 2 and 5 minutes were compared. The 5-minute extraction time had significantly higher total phenolic content compared with the 2-minute extraction time. Choice Darjeeling 5-minute extraction yielded the highest amount of total phenolics (299.6±5.9 mg/g), followed by Tazo Black 5-minute extraction (240±9.7 mg/g), whereas Bigelow Green 2-minute extraction had the lowest total phenolic content (53±8.2 mg/g). 1,1-Diphenyl-2-picrylhydrazyl scavenging-linked antioxidant activity was high (81–91%) for all types evaluated, and for most samples it was influenced by the extraction time. Similarly, high in vitro α-glucosidase inhibition was observed in almost all the samples assayed, and for most samples the 5-minute extraction had significantly higher inhibition compared with the 2-minute extraction time. The most fermented teas showed highest α-amylase inhibition: Choice Darjeeling 5-minute extraction had the highest inhibition (84.1%), followed by Tazo Black 5-minute extraction (71.6%). Angiotensin converting enzyme inhibition was not observed in any sample. Overall, the 5-minute extraction time was found to have more relevance for potential benefits for managing hyperglycemia than the 2-minute procedure. This research suggests that tea offers an attractive potential strategy to regulate postprandial hyperglycemia toward an overall dietary support for type 2 diabetes management.
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Chandrakant Ankolekar,David Johnson,Marcia da Silva Pinto,Kevin Johnson,Ronald Labbe,Kalidas Shetty 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.11
Tea polyphenolics such as catechins are known to have the potential to inhibit many bacterial pathogens. Helicobacter pylori has been identified as an etiologic agent in the development of gastric ulcer, peptic ulcer, gastritis, and many other stomach-related diseases. In this study, we investigated the effect of 9 tea extracts—3 different brands representing 4 different processed types (white, green, oolong, and black)—on the inhibition of H. pylori. Extraction times of 2 and 5 minutes were compared. Most 5-minute extracts showed H. pylori inhibition, whereas 2-minute extracts only of Choice darjeeling black and Tazo white showed inhibition. No recovery was observed after the addition of 0.5 and 5 mM proline, indicating that tea polyphenols do not inhibit H. pylori by inhibition of proline oxidation via proline dehydrogenase. Extracts that showed inhibition were further evaluated for their effect on beneficial lactic acid bacteria. None of the samples showed inhibition, suggesting that tea might be able to inhibit H. pylori without affecting the beneficial lactic acid bacteria. High-performance liquid chromatography indicated the presence of gallic acid, quercetin, caffeine, and tea catechins (including catechin, epicatechin, and epigallocatechin) in all the tea samples. Our study indicates that tea can be potentially used as a low-cost dietary support to combat H. pylori–linked gastric diseases without affecting the beneficial intestinal bacteria.
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Ana Cristina Lopes Barbosa,Marcia da Silva Pinto,Dipayan Sarkar,Chandrakant Ankolekar,Duane Greene,Kalidas Shetty 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.6
The well-known health benefits of apples have been attributed in part to the presence of polyphenols and related antioxidant capacity. The consumption of apples could provide health benefits by reducing the risk for chronic diseases such as metabolic syndrome disease, including type 2 diabetes. Thus, the objective of this study was to investigate the phenolic-linked antihyperglycemia bioactive factors in aqueous and 12% ethanol extracts of peel and pulp from 10 different freshly harvested apple varieties commonly consumed in the United States. The extracts were analyzed for total soluble phenolics, 2,2-diphenyl-1-picrylhydrazyl-linked antioxidant activity, and their associated in vitro a-glucosidase and a-amylase inhibitory activities. In general, peel extracts had higher total soluble phenolic content and related antioxidant capacity than pulp extracts. Quercetin derivatives, protocatechuic acid, chlorogenic acid, and p-coumaric acid were detected, and the amount varied significantly between aqueous and ethanolic extracts. Honeycrisp and Red Delicious varieties had the highest total phenolic contents and a significant correlation with antioxidant capacity (r¼0.91). In addition, high a-amylase and a-glucosidase inhibitory activities in aqueous pulp extracts were found. However, the peel extracts had the highest a-glucosidase inhibitory activity along with low a-amylase inhibitory activity. No correlation between a-amylase inhibitory activity and total phenolic content was observed. However, positive correlations between a-glucosidase inhibitory activity and total phenolics in aqueous (r¼0.50) and ethanolic (r¼0.70) extracts were observed. This study provides the biochemical rationale for animal and clinical studies to determine the suitable varieties with optimum bioactive factors with antihyperglycemia potential.
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