http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Carlsen, Rebecca (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma
Ally, Adrian,Balasundaram, Miruna,Carlsen, Rebecca,Chuah, Eric,Clarke, Amanda,Dhalla, Noreen,Holt, Robert A.,Jones, Steven J.M.,Lee, Darlene,Ma, Yussanne,Marra, Marco A.,Mayo, Michael,Moore, Richard A Elsevier 2017 Cell Vol.169 No.7
<P><B>Summary</B></P> <P>Liver cancer has the second highest worldwide cancer mortality rate and has limited therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome sequencing and DNA copy number analyses, and we analyzed 196 HCC cases by DNA methylation, RNA, miRNA, and proteomic expression also. DNA sequencing and mutation analysis identified significantly mutated genes, including <I>LZTR1</I>, <I>EEF1A1</I>, <I>SF3B1</I>, and <I>SMARCA4</I>. Significant alterations by mutation or downregulation by hypermethylation in genes likely to result in HCC metabolic reprogramming (<I>ALB</I>, <I>APOB</I>, and <I>CPS1</I>) were observed. Integrative molecular HCC subtyping incorporating unsupervised clustering of five data platforms identified three subtypes, one of which was associated with poorer prognosis in three HCC cohorts. Integrated analyses enabled development of a p53 target gene expression signature correlating with poor survival. Potential therapeutic targets for which inhibitors exist include WNT signaling, MDM4, MET, VEGFA, MCL1, IDH1, TERT, and immune checkpoint proteins CTLA-4, PD-1, and PD-L1.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Analysis of hepatocellular carcinomas integrates data of multiple genomic platforms </LI> <LI> Mutated genes reveal oncogenic processes altering hepatocyte energy balance </LI> <LI> Multiplex analyses suggest a key role for Sonic hedgehog signaling in HCC </LI> <LI> IDH mutations point to a HCC subgroup molecularly similar to cholangiocarcinoma </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
-
Current practices and recent advances in condition assessment of aged ships
Rizzo, C. M.,Paik, J. K.,Brennan, F.,Carlsen, C. A.,Daley, C.,Garbatov, Y.,Ivanov, L.,Simonsen, B. C.,Yamamoto, N.,Zhuang, H. Z. Taylor Francis 2007 SHIPS AND OFFSHORE STRUCTURES Vol.2 No.3
<P> Ship structures are likely to be subject to age-related deterioration such as corrosion wastage, cracking or mechanical damage. It has reportedly been recognised that such age-related deterioration is almost always involved in the catastrophic failures of ship structures including total losses. While such accidents typically cause concern to the public, maintenance and repair of aged structures is quite costly and complex. It is thus of great importance to develop advanced technologies allowing for proper management and control of such age-related deterioration. This paper summarises the report of the ISSC 2006 Committee V.6 presenting current practices, recent advances and future trends on condition assessment of aged ships. This includes assessment of the structural condition in view of the serviceability and safety, methods for repair, quantification of strength of deteriorated and repaired ships (as well as criteria for acceptable damage), with due account of the uncertainties involved. Consideration is also given to cost-benefit and risk-based decision procedures for remedial actions.</P>
-
Henriette Arnesen,Mette Helen Bjørge Müller,Mona Aleksandersen,Gunn Charlotte Østby,Harald Carlsen,Jan Erik Paulsen,Preben Boysen 한국실험동물학회 2021 Laboratory Animal Research Vol.37 No.3
Background Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide and thus mouse models of CRC are of significant value to study the pathogenesis. The Azoxymethane/Dextran sulfate sodium (AOM/DSS) model is a widely used, robust initiation-promotion model for chemical induction of colitis-associated CRC in rodents. However, the dosage of chemicals, treatment regimens and outcome measures vary greatly among studies employing this model. Thus, the aim of this study was to examine an AOM/DSS model involving a reduced (1%) dose of DSS for induction of carcinogenesis in A/J and C57BL/6J (B6) mice. Results We show that colonic preneoplastic lesions can be reliably detected in A/J and B6 mice by use of a AOM/DSS model involving a single injection of 10 mg/kg AOM followed by three 7-day cycles of a low-dose (1%) DSS administration. Supporting existing evidence of A/J mice exhibiting higher susceptibility to AOM than B6 mice, our AOM/DSS-treated A/J mice developed the highest number of large colonic lesions. Clinical symptoms in both strains subjected to the AOM/DSS treatment did not persist in-between treatment cycles, demonstrating that the animals tolerated the treatment well. Conclusions Our findings suggest that a reduced dose of DSS in the AOM/DSS model can be considered in future studies of early phase colorectal carcinogenesis in the A/J and B6 mouse strains using preneoplastic lesions as an outcome measure, and that such regimen may reduce the risk of early trial terminations to accommodate human endpoints. Overall, our data emphasize the importance of devoting attention towards choice of protocol, outcome measures and mouse strain in studies of CRC in mice according to the study purpose.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
