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RISS 인기검색어
- 검색키워드
- 저자 : Carla Teixeira (검색결과 3 건)
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Clinical and radiographic characteristics of pycnodysostosis: A systematic review
Goes Gonzaga Amanda Katarinny,de Oliveira Costa Carla Samily,de Farias Morais Hannah Gil,da Fonseca Neto Braz,Pinto Leão Pereira,Maciel Dantas Wagner Ranier,de Oliveira Patricia Teixeira,de Melo Danie 대한영상치의학회 2024 Imaging Science in Dentistry Vol.54 No.1
Purpose: Pycnodysostosis (PYCD), an autosomal recessive syndrome, is characterized by an imbalance in bone remodeling that produces various clinical and radiographic craniofacial manifestations. This review represents a systematic examination of these manifestations, as well as oral features associated with PYCD. Materials and Methods: A systematic review was conducted across 8 databases from February to March 2023. The search strategy focused on studies reporting cases of PYCD that examined the clinical and radiographic craniofacial and oral characteristics associated with this syndrome. Results: The review included 84 studies, encompassing a total of 179 cases of PYCD. More than half of the patients were female (55.3%), and the mean age was 14.7 years. Parental consanguinity was reported in 51.4% of the cases. The most common craniofacial clinical manifestation was a prominent nose, observed in 57.5% of cases. Radiographically, the most frequently reported craniofacial characteristics included the presence of an obtuse mandibular angle (84.3%) and frontal cranial bosses (82.1%). Clinical and radiographic examinations revealed oral alterations, with micrognathia present in 62.6% of patients and malocclusion in 59.2%. Among dental anomalies, tooth agenesis was the most commonly reported, affecting 15.6% of patients. Conclusion: Understanding the clinical and radiographic craniofacial features of PYCD is crucial for dental professionals. This knowledge enables these clinicians to devise effective treatment plans and improve patient quality of life.
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Nosocomial meningitis in intensive care: a 10-year retrospective study and literature review
Sofia R. Valdoleiros,Cristina Torrão,Laura S. Freitas,Diana Mano,Celina Gonçalves,Carla Teixeira 대한중환자의학회 2022 Acute and Critical Care Vol.37 No.1
Background: Nosocomial meningitis is a medical emergency that requires early diagnosis, prompt initiation of therapy, and frequent admission to the intensive care unit (ICU).Methods: A retrospective study was conducted in adult patients diagnosed with nosocomial meningitis who required admission to the ICU between April 2010 and March 2020. Meningitis/ventriculitis and intracranial infection were defined according to Centers for Disease Control and Prevention guidelines.Results: An incidence of 0.75% of nosocomial meningitis was observed among 70 patients. The mean patient age was 59 years and 34% were ≥65 years. Twenty-two percent of patients were in an immunocompromised state. A clear predisposing factor for nosocomial meningitis (traumatic brain injury, basal skull fracture, brain hemorrhage, central nervous system [CNS] invasive procedure or device) was present in 93% of patients. Fever was the most frequent clinical feature. A microbiological agent was identified in 30% of cases, of which 27% were bacteria, with a predominance of Gram-negative over Gram-positive. Complications developed in 47% of cases, 24% of patients were discharged with a Glasgow coma scale <14, and 37% died. No clinical predictor of complications was identified. Advanced age (≥65 years old) and presence of complications were associated with higher hospital mortality. Conclusions: Nosocomial meningitis in intensive care has a low incidence rate but high mortality and morbidity. In a critical care patient with CNS-related risk factors, a high level of suspicion for meningitis must be employed, but diagnosis is hindered by several confounding factors.
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Assessment of Beneficial and Possible Toxic Effects of Two New Alfalfa-Derived Shelf Products
Maria G. Soto-Zarazua,Moustapha Bah,Maria G. Garcia-Alcocer,Laura C. Berumen,Carla Sofia Costa,Maria Joao Bessa,Francisca Rodrigues,Joao Paulo Teixeira,Maria Beatriz P.P. Oliveira 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.10
Aerial parts of Medicago sativa L. have been used as food and its consumption has been associated with health benefits, one among the most important being menopausal symptoms control. This work was aimed to explore possible pharmacological effects of two new alfalfa-derived products that have recently emerged as daily beverage preparations. In exploring their potential estrogenic effects, they produced no relevant alteration in the uterus. However, lowering glucose levels until normal values without causing further hypoglycemic effect were observed, when rats were treated with 1.5 g/kg/day samples. In vivo acute toxicity was not found when the alfalfa products were tested up to 3 g/kg rat weight. Furthermore, in vitro studies were conducted to assess their possible toxic effects. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase tests were carried out on the Caco-2 cell model to determine cell viability and membrane integrity. A concentration-dependent effect was observed, with a significant decrease in cell viability after exposure to concentrations of alfalfa product up to 100 mg/mL (after 3 h of incubation) and 50 mg/mL (after 24 h of treatment). Although in vitro level, the decrease in cell viability at these still low doses may underlie some toxicity, making necessary additional studies before any recommendation of a sustained consumption of these products by humans.
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