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Lkhagvadulam, Byambajav,Kim, Jung Hwa,Yoon, Il,Shim, Young Key Hindawi Publishing Corporation 2013 BioMed research international Vol.2013 No.-
<P>Gold nanoparticles (GNPs) conjugates of water soluble ionic photosensitizer (PS), purpurin-18-<I>N</I>-methyl-<I>D</I>-glucamine (Pu-18-NMGA), were synthesized using various molar ratios between HAuCl<SUB>4</SUB> and Pu-18-NMGA without adding any particular reducing agents and surfactants. The PS-GNPs conjugates showed long wavelength absorption of range 702–762 nm, and their different shapes and diameters depend on the molar ratios used in the synthesis. <I>In vitro</I> anticancer efficacy of the PS-GNPs conjugates was investigated by MTT assay against A549 cells, resulting in higher photodynamic activity than that of the free Pu-18-NMGA. Among the PS-GNPs conjugates, the GNPs conjugate from the molar ratio of 1 : 2 (Au(III): Pu-18-NMGA) exhibits the highest photodynamic activity corresponding to bigger size (~60 nm) of the GNPs conjugate which could efficiently transport the PS into the cells than that of smaller size of the GNPs conjugate.</P>
Yoon, Il,Park, Ho-Sung,Cui, Bing Cun,Li, Jia Zhu,Kim, Jung-Hwa,Lkhagvadulam, Byambajav,Shim, Young-Key Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.suppl8
A comparative study of the photodynamic and antioxidant activities of methyl pheophorbide-a (MPa, 1) and its transition metal(II) complexes (2-5) is described. Four transition metal complexes (palladium(II): 2, zinc(II): 3, cobalt(II): 4 and copper(II): 5) of MPa were prepared by reaction between the corresponding transition metal and 1, respectively, and were characterized by $^1H$-NMR and UV-vis spectroscopic and mass spectrometric analyses. In vitro results show a photodynamic therapy (PDT) efficacy with A549 cells might be attributed to a heavy atom effect of the transition metal complexes of MPa. Among them, 4 and 5 showed higher photodynamic activity than that of 1 at the concentration of 5 ${\mu}M$ at 24 h incubation after photoirradiation. The images of morphological change for 2-5 show evidence for the PDT effect with A549 cells. And the all transition metal complexes of MPa showed higher antioxidant activity than that of MPa, in which 4 showed the highest antioxidant activity.
Il Yoon,Ho Sung Park,Bing Cun Cui,Jia Zhu Li,Jung Hwa Kim,Byambajav Lkhagvadulam,Young Key Shim 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.8
A comparative study of the photodynamic and antioxidant activities of methyl pheophorbide-a (MPa, 1) and its transition metal(II) complexes (2-5) is described. Four transition metal complexes (palladium(II): 2, zinc(II):3, cobalt(II): 4 and copper(II): 5) of MPa were prepared by reaction between the corresponding transition metal and 1, respectively, and were characterized by 1H-NMR and UV-vis spectroscopic and mass spectrometric analyses. In vitro results show a photodynamic therapy (PDT) efficacy with A549 cells might be attributed to a heavy atom effect of the transition metal complexes of MPa. Among them, 4 and 5 showed higher photodynamic activity than that of 1 at the concentration of 5 μM at 24 h incubation after photoirradiation. The images of morphological change for 2-5 show evidence for the PDT effect with A549 cells. And the all transition metal complexes of MPa showed higher antioxidant activity than that of MPa, in which 4 showed the highest antioxidant activity.