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Predicting the failure modes of monotonically loaded reinforced concrete exterior beam-column joints
Bakir, Pelin G.,Boduroglu, Hasan M. Techno-Press 2002 Structural Engineering and Mechanics, An Int'l Jou Vol.14 No.3
This study aims at postulating a simple methodology for predicting the failure modes of monotonically loaded reinforced concrete beam-column joints. All the factors that affect the failure modes of joints are discussed in detail using an experimental database of monotonically loaded exterior beam-column joints. The relative contributions of the strut and truss mechanisms to joint shear strength are determined based on the test results. A simple design equation for the beam longitudinal reinforcement ratio for joints with low, medium and high amount of stirrups is developed. The factors influencing the failure modes of monotonically loaded exterior beam-column joints are investigated in detail. Design charts that predict the failure modes of exterior beam-column connections both with and without stirrups are developed. Experimental data are compared with the design charts. The results show that the simple methodology gives very accurate predictions of the failure modes.
Guvenoglu, Merve,Simsek-Kiper, Pelin Ozlem,Kosukcu, Can,Taskiran, Ekim Z.,Saltik-Temizel, Inci Nur,Gucer, Safak,Utine, Eda,Boduroglu, Koray The Korean Society of Pediatric Gastroenterology 2022 Pediatric gastroenterology, hepatology & nutrition Vol.25 No.6
Congenital diarrheal disorders (CDDs) with genetic etiology are uncommon hereditary intestinal diseases characterized by chronic, life-threatening, intractable watery diarrhea that starts in infancy. CDDs can be mechanistically divided into osmotic and secretory diarrhea. Congenital tufting enteropathy (CTE), also known as intestinal epithelial dysplasia, is a type of secretory CDD. CTE is a rare autosomal recessive enteropathy that presents with intractable neonatal-onset diarrhea, intestinal failure, severe malnutrition, and parenteral nutrition dependence. Villous atrophy of the intestinal epithelium, crypt hyperplasia, and irregularity of surface enterocytes are the specific pathological findings of CTE. The small intestine and occasionally the colonic mucosa include focal epithelial tufts. In 2008, Sivagnanam et al. discovered that mutations in the epithelial cell adhesion molecule (EpCAM, MIM# 185535) were the genetic cause of CTE (MIM# 613217). More than a hundred mutations have been reported to date. Furthermore, mutations in the serine peptidase inhibitor Kunitz type 2 (SPINT2, MIM# 605124) have been linked to syndromic CTE. In this study, we report the case of a 17-month-old male infant with congenital diarrhea. Despite extensive etiological workup, no etiology could be established before admission to our center. The patient died 15 hours after being admitted to our center in a metabolically decompensated state, probably due to a delay in admission and diagnosis. Molecular autopsy with exome sequencing revealed a previously reported homozygous missense variant, c.757G>A, in EpCAM, which was confirmed by histopathological examination.