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Hamacher, Michael,Apweiler, Rolf,Arnold, Georg,Becker, Albert,Blü,ggel, Martin,Carrette, Odile,Colvis, Christine,Dunn, Michael J.,Frö,hlich, Thomas,Fountoulakis, Michael,van Hall, André WILEY-VCH Verlag 2006 Proteomics Vol.6 No.18
<P>The Human Proteome Organisation (HUPO) initiated several projects focusing on the proteome analysis of distinct human organs. The Brain Proteome Project (BPP) is the initiative dedicated to the brain, its development and correlated diseases. Two pilot studies have been performed aiming at the comparison of techniques, laboratories and approaches. With the help of the results gained, objective data submission, storage and reprocessing workflow have been established. The biological relevance of the data will be drawn from the inter-laboratory comparisons as well as from the re-calculation of all data sets submitted by the different groups. In the following, results of the single groups as well as the centralised reprocessing effort will be summarised and compared, showing the added value of this concerted work.</P>
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Yoo, H. J.,Hwang, S. Y.,Cho, G. J.,Hong, H. C.,Choi, H. Y.,Hwang, T. G.,Kim, S. M.,Blü,her, Matthias,Youn, Byung-Soo,Baik, S. H.,Choi, K. M. The Endocrine Society 2013 The Journal of clinical endocrinology & metabolism Vol.98 No.7
<P><B>Context and Objective:</B></P><P>Glypican-4 was identified as a novel adipokine capable of enhancing insulin signaling and modulating adipocyte differentiation. We investigated associations between glypican-4 and body composition, insulin resistance, arterial stiffness, and nonalcoholic fatty liver disease (NAFLD) in nondiabetic Asian subjects.</P><P><B>Design and Participants:</B></P><P>We analyzed baseline cross-sectional data from the Korean Sarcopenic Obesity Study, an ongoing prospective cohort study. NAFLD was diagnosed by unenhanced computed tomography using the liver attenuation index. We also examined the effects of a 3-month combined aerobic and resistance exercise program on glypican-4 levels and cardiometabolic risk factors.</P><P><B>Results:</B></P><P>Circulating glypican-4 levels were higher in men than in women (1.83 [1.19, 2.78] ng/mL vs 1.17 [0.66, 2.00] ng/mL, <I>P</I> < .001) and had a significant positive relationship with the waist-to-hip ratio (WHR) (<I>r</I> = 0.20, <I>P</I> = .014) and the ratio of visceral to sc fat area (<I>r</I> = 0.30, <I>P</I> < .001). Furthermore, glypican-4 levels in women were correlated with cardiometabolic risk factors, including insulin resistance and arterial stiffness, and were independently associated with NAFLD by multiple logistic regression analysis (<I>P</I> = .017, <I>R</I><SUP>2</SUP> = 0.33). The 3-month combined exercise training program significantly improved several cardiometabolic parameters and reduced retinol binding protein-4 levels. Changes in glypican-4 levels after the exercise program were significantly different between subjects with an increased WHR compared with those with a decreased WHR (<I>P</I> = .034).</P><P><B>Conclusion:</B></P><P>A gender-based difference in circulating glypican-4 levels was apparent as these were increased in women with NAFLD and related to body fat distribution, insulin resistance, and arterial stiffness.</P>
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