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RISS 인기검색어
- 검색키워드
- 저자 : Bhutada, Rupesh Nandkumar (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Otari, Kishor Vasant,Shete, Rajkumar Virbhadrappa,Bhutada, Rupesh Nandkumar,Upasani, Chandrashekhar Devidas 경희한의학연구센터 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.3
The present work was aimed to assess the effect of ammonium glycyrrhizinate, $AG$ (50, 100, and 150 mg/kg, i.p.) on haloperidol induced catalepsy in mice; reserpine induced orofacial dyskinesia in rats; and reserpine antagonism in mice. Additionally the effect of $AG$ on lipid peroxidation (LP) in cataleptic mice brain and monoamine oxidase-B (MAO-B) levels in normal mice brain was assessed. Administration of $AG$ 100 and 150 mg/kg showed significant reduction in the duration of cataleptic behavior at 60 to 180 min and dose dependent decrease in LP induced by haloperidol. $AG$ showed significant decrease in frequency of vacuous chewing movements at 150 mg/kg and frequency of tongue protrusion at 100 and 150 mg/kg in reserpine induced orofacial dyskinesia test. $AG$ showed significant increase in frequency of horizontal movement and rearing behavior at 150 mg/kg and increase in grooming behavior at 100 and 150 mg/kg in reserpine antagonism test. $AG$ showed dose dependent inhibition of MAO-B in the normal mice brain. These results suggested that $AG$ prevented the haloperidol- and reserpine- induced neurobehavioral alterations possibly by acting as free radical scavenger or inhibiting MAO-B thereby increasing dopaminergic transmition consequently decreasing dopamine metabolites and ultimately preventing the generation of free radicals.
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Clinical and Social Outcomes of Cochlear Implantation in Older Prelinguals
Tyagi Pragya,Chauhan Divya,Singh Anup,Bhutada Mayank,Sikka Kapil,Chaudhary Tanvi,Sharma Sonam,Agarwal Shivani,Verma Hitesh,Sagar Prem,Kumar Rakesh,Thakar Alok 대한청각학회 2023 Journal of Audiology & Otology Vol.27 No.2
Background and Objectives: Cochlear implantation in late implanted prelinguals necessitates a complex decision-making process for clinicians and patients due to the uncertainty of achieving adequate benefit in auditory and speech perception. This study longitudinally evaluated clinical and social outcomes of prelingually deaf children with implantation in their late childhood.Subjects and Methods: A total of 113 (49 females and 64 males) participants, with an age range of 5-15 years, were assessed for the pre-implant parameters such as hearing loss etiology, aided responses, anatomical aspects, and psychological evaluation. The Category of Auditory Performance, Speech Awareness Threshold, Speech Reception Threshold, and Speech Discrimination Score were administered to assess the patient’s auditory skills. Further, the Speech Intelligibility Rating scale was administered to evaluate the patient’s speech intelligibility at 3, 6, 9, 12, 18, and 24 months post-surgery. Subjectively perceived benefits were evaluated using the satisfaction rating scale and a questionnaire.Results: The statistical results showed a significant impact of cochlear implantation in all domains. Positive impact and improvement post-implantation were noted in all the spheres, including auditory, linguistic, social, and educational.Conclusions: The study highlighted that the outcomes of a cochlear implant at a later age might not parallel with the implantation at a younger age. However, this still provides measurable benefits even after a longer period of auditory deprivation.
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Kishor Vasant Otari,Rajkumar Virbhadrappa Shete,Rupesh Nandkumar Bhutada,Chandrashekhar Devidas Upasani 경희대학교 융합한의과학연구소 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.3
The present work was aimed to assess the effect of ammonium glycyrrhizinate, AG (50, 100, and 150 mg/kg,i.p.) on haloperidol induced catalepsy in mice; reserpine induced orofacial dyskinesia in rats; and reserpine antagonism in mice. Additionally the effect of AG on lipid peroxidation (LP) in cataleptic mice brain and monoamine oxidase-B (MAO-B) levels in normal mice brain was assessed. Administration of AG 100 and 150 mg/kg showed significant reduction in the duration of cataleptic behavior at 60 to 180 min and dose dependent decrease in LP induced by haloperidol. AG showed significant decrease in frequency of vacuous chewing movements at 150 mg/kg and frequency of tongue protrusion at 100 and 150 mg/kg in reserpine induced orofacial dyskinesia test. AG showed significant increase in frequency of horizontal movement and rearing behavior at 150 mg/kg and increase in grooming behavior at 100 and 150 mg/kg in reserpine antagonism test. AG showed dose dependent inhibition of MAO-B in the normal mice brain. These results suggested that AG prevented the haloperidol- and reserpine- induced neurobehavioral alterations possibly by acting as free radical scavenger or inhibiting MAO-B thereby increasing dopaminergic transmition consequently decreasing dopamine metabolites and ultimately preventing the generation of free radicals.
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