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RISS 인기검색어
- 검색키워드
- 저자 : Baoyu Jia (검색결과 3 건)
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Baoyue Li,Yonghua Yu,Jia Hu,Bingxin Cao,Yangfeng Yao,Defeng Xu 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.12
The vibration signal of rotating mechanical equipment contains a large amount of information that can be used for the fault diagnosis of rotating mechanical equipment. However, the vibration information is distributed in multiple dimensions, and a single-scale analysis cannot effectively reflect its damage characteristics, reducing the accuracy of fault diagnosis. Accordingly, an improved hierarchical fluctuation dispersion entropy (MHFDE) method based on the improved hierarchical processing is proposed. MHFDE can simultaneously mine low- and highfrequency features in the time series, avoiding information omission. Comparison results of the simulated signals show that the proposed method has the advantages of high stability and accurate measurement of complexity. In combination with the multi-cluster feature selection (MCFS) and kernel limit learning machine (KELM) optimized by whale optimization algorithm (WOA), a rotating machinery damage recognition method based on MHFDE-MCFS and WOA-KEM was proposed. Three sets of typical rotating machinery datasets are used to verify the effectiveness of the proposed method. The results show that this method can not only accurately and stably identify the damage types of the three selected machinery but also have a higher accuracy of damage recognition compared with the existing feature extraction methods.
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Differences in the starvation-induced autophagy response in MDA-MB-231 and MCF-7 breast cancer cells
Wanyun Zhu,Hong-Jiang Wei,Hong-Ye Zhao,Hao Qu,Kaixiang Xu,Baoyu Jia,Haifeng Li,Yimin Du,Guangming Liu 한국통합생물학회 2017 Animal cells and systems Vol.21 No.3
Breast cancer is a heterogeneous disease with distinct subtypes that have made targeted therapy of breast cancer challenging. Previous studies have demonstrated that an altered autophagy capacity can influence the development of breast cancer. However, the molecular differences in starvationinduced autophagic responses in MDA-MB-231 and MCF-7 cells have not been fully elucidated. In this study, we found that an increase of LC3B-II protein expression level and a decrease of the p62 protein expression level in both cells treated by Earle’s balanced salt solution. Meanwhile, we observed an increase of autophagosome using transmission electron microscopy and an enhancement in the green fluorescence intensity of LC3B protein by confocal microscopy. Furthermore, we detected the expression of 13 autophagy-related (ATG) genes and 11 autophagy signaling pathway-related genes using qPCR. Among 13 ATG genes, we found that 6 genes were up-regulated in treated MDA-MB-231 cells, while 4 genes were up-regulated and 1 gene was down-regulated in treated MCF-7 cells. In addition, among 11 autophagy signaling pathway-related genes, 7 genes were up-regulated in treated MDA-MB-231 cells, while 5 genes were up-regulated and 1 gene was down-regulated in treated MCF-7 cells. These findings suggest that the autophagic response to starvation was different in the two treated cell lines, which will contribute to further study on the molecular mechanism of starvation-induced autophagy and improve the targeted therapy of breast cancer.
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Endogenous leptin promotes autophagy in EBSS-induced PFCs
Deling Jiao,Zhen Yang,Lulu Wang,Binyue Hu,Jing Wang,Anyong Xu,Wenmin Cheng,Baoyu Jia,Yubo Qing,Hong-Ye Zhao,Hong-Jiang Wei 한국통합생물학회 2019 Animal cells and systems Vol.23 No.5
Leptin is an important adipokine and plays a vital role in animals. However, the role of leptin in the autophagic response of pig fibroblast cells (PFCs) has not been fully elucidated. In this study, we investigated the relationship between leptin and autophagy as well as underlying molecular basis. We found that PFCs treated with EBSS could secrete leptin, and the leptin concentration in the supernatant of leptin transgenic PFCs was higher than that of WT PFCs. We found an increase in LC3-II protein level and a decrease in p62 protein level in treated leptin transgenic PFCs compared with treated WT PFCs. Meanwhile, we observed an increase of autophagosomes by transmission electron microscopy and an enhancement of the accumulation of LC3 puncta in the cytoplasm of treated leptin transgenic PFCs, and these effects were further augmented by Baf A1 treatment. Furthermore, we detected the expression levels of 7 autophagy signaling pathway genes and 17 autophagy-related (ATG) genes by q-PCR. We found that between the two types of EBSS-treated cells 3 genes expression pattern were significantly different among the 7 autophagy signaling pathway genes and 8 genes expression pattern were significantly differernt among the ATG genes. These results indicated that leptin may promote autophagy and involving the downregulation of FOXO1 and LMNA genes via an unknown pathway which causes the upregulation of the 4 genes and the downregulation of 4 genes.
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