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- 저자 : Baowei Wu (검색결과 3 건)
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Glioma Stem Cell-Targeted Dendritic Cells as a Tumor Vaccine Against Malignant Glioma
Baowei Ji,Qianxue Chen,Baohui Liu,Liquan Wu,Daofeng Tian,Zhentao Guo,Wei Yi 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.1
Purpose: Cancer stem cells have recently been thought to be closely related to tumor development and reoccurrence. It may be a promising way to cure malignant glioma by using glioma stem cell-targeted dendritic cells as a tumor vaccine. In this study, we explored whether pulsing dendritic cells with antigens of glioma stem cells was a potent way to induce specific cytotoxic T lymphocytes and anti-tumor immunity. Materials and Methods: Cancer stem cells were cultured from glioma cell line U251. Lysate of glioma stem cells was obtained by the repeated freezing and thawing method. Dendritic cells (DCs) were induced and cultured from the murine bone marrow cells, the biological characteristics were detected by electron microscope and flow cytometry. The DC vaccine was obtained by mixing DCs with lysate of glioma stem cells. The DC vaccine was charactirizated through the mixed lymphocyte responses and cell killing experiment in vitro. Level of interferon-γ (IFN-γ) in the supernatant was checked by ELISA. Results: After stimulation of lysate of glioma stem cell, expression of surface molecules of DC was up-regulated, including CD80, CD86, CD11C and MHC-II. DCs pulsed with lysate of glioma stem cells were more effective than the control group in stimulating original glioma cells-specific cytotoxic T lymphocytes responses, killing glioma cells and boosting the secretion of IFN-γ in vitro. Conclusion: The results demonstrated DCs loaded with antigens derived from glioma stem cells can effectively stimulate naive T cells to form specific cytotoxic T cells, kill glioma cells cultured in vitro.
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Input-output Finite-time Stability of Switched Singular Continuous-time Systems
Tian Feng,Baowei Wu,Yue-E Wang,YangQuan Chen 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.5
This paper is concerned with the problem of input-output finite-time stability (IO-FTS) for a class of switched singular continuous-time systems. First, the concept of IO-FTS is extended to switched singular systems. Then, by using the average dwell time switching approach and constructing multiple Lyapunov functions, a sufficient condition of IO-FTS for the considered system is presented in the form of linear matrix inequalities (LMIs). Furthermore, based on the derived conditions, a suitable state feedback controller is designed to stabilize the switched singular systems. Finally, an illustrative example is provided to demonstrate the effectiveness of the proposed technique.
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Mingxing Liu,Baowei Wu,Yue-E Wang,Lili Liu 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.2
This paper is concerned with dynamic quantized output feedback and event-triggered guaranteed cost finite-time H∞ control for uncertain switched linear systems with exogenous disturbance. First, one mode-dependent periodic event-triggered strategy is designed, which means that each subsystem has its own event-triggered mechanism. Meanwhile, the periodic detection of the error greatly reduces the sampling number and avoids the appearance of Zeno behavior. Second, considering the state information of the system is difficult to obtain completely, dynamic quantized output feedback controllers based on logarithmic quantizer are used to stabilize the switched system. Besides, combine the multiple Lyapunov functionals and the average dwell time condition, the sufficient condition of finite-time boundedness with H∞ performance level is obtained for the uncertain switched system. Finally, the effectiveness of the proposed method is verified a practical example.
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