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Dual targeting of EphA2 and FAK in ovarian carcinoma.
Shahzad, Mian M K,Lu, Chunhua,Lee, Jeong-Won,Stone, Rebecca L,Mitra, Rahul,Mangala, Lingegowda S,Lu, Yiling,Baggerly, Keith A,Danes, Christopher G,Nick, Alpa M,Halder, Jyotsnabaran,Kim, Hye-Sun,Vivas- Landes Bioscience 2009 Cancer Biology & Therapy Vol.8 No.11
<P>EphA2 gene silencing has been shown to result in antitumor efficacy. Here we considered whether silencing additional targets downstream of EphA2 would further enhance the therapeutic effect. EphA2 targeted siRNA was tested in combination with either FAK or Src targeted siRNA using DOPC nanoliposomes in orthotopic models of ovarian carcinoma. The effects of therapy were determined by changes in tumor weight, proliferation (Ki-67), and microvessel density (CD31). In our initial in vivo study, EphA2 plus FAK silencing resulted in the greatest reduction in tumor growth (by 73%, p < 0.005) as compared to control siRNA alone. In the SKOV3ip1 and HeyA8 ovarian cancer models, EphA2 siRNA-DOPC treatment resulted in a 50-67% decrease in tumor growth (p < 0.02, for both), and FAK siRNA-DOPC resulted in a 61-62% decrease in tumor growth (p < 0.009, p < 0.05, respectively). EphA2 plus FAK siRNA-DOPC treatment resulted in a significant reduction (SKOV3ip1: 76%, p < 0.007, HeyA8: 90%, p < 0.003) in tumor growth compared to control siRNA-DOPC. Combination treatment with EphA2 + FAK siRNA-DOPC resulted in significant decreases in tumor cell proliferation (p < 0.001) and microvessel density compared to control siRNA-DOPC (80%; p < 0.001), or the monotherapy groups (p values <0.001). These data suggest that the antitumor efficacy of in vivo EphA2 targeting is enhanced in combination with FAK silencing. Dual targeting of EphA2 and FAK may have therapeutic implications for ovarian cancer management.</P>
Physics at the [FORMULA OMISSION] linear collider
Moortgat-Pick, G.,Baer, H.,Battaglia, M.,Belanger, G.,Fujii, K.,Kalinowski, J.,Heinemeyer, S.,Kiyo, Y.,Olive, K.,Simon, F.,Uwer, P.,Wackeroth, D.,Zerwas, P. M.,Arbey, A.,Asano, M.,Bagger, J.,Bechtle, Springer Berlin Heidelberg 2015 European Physical Journal C Vol.75 No.8
<P>A comprehensive review of physics at an [FORMULA OMISSION] linear collider in the energy range of [FORMULA OMISSION] GeV–3 TeV is presented in view of recent and expected LHC results, experiments from low-energy as well as astroparticle physics. The report focusses in particular on Higgs-boson, top-quark and electroweak precision physics, but also discusses several models of beyond the standard model physics such as supersymmetry, little Higgs models and extra gauge bosons. The connection to cosmology has been analysed as well.</P>