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Mohammad Tarique1,Badruddeen,Farogh Ahsan,Juber Akhtar,Mohammad Irfan Khan,Mohammad Khalid 경희대학교 융합한의과학연구소 2019 Oriental Pharmacy and Experimental Medicine Vol.19 No.4
The present study aims at formulation development and pharmacological evaluation of fxed dose combination of Bombyx mori (Abresham) extract, Flaxseed oil and coenzyme Q10 (CoQ10) against doxorubicin induced myocardial toxicity in rats. Formulation (emulsion) was prepared using dry gum method (continental method), by using pestle and mortar. The formulation was characterized by performing stability studies which includes focculation and creaming, cracking, phase inversion and accelerated studies (temperature and light). In-vivo pharmacological evaluation of Bombyx mori extract, Flaxseed oil, CoQ10 and its fxed dose combination (FDC) were then performed. Results obtained indicates that developed FDC and extract, Oil, CoQ10 passed all stability tests and signifcantly prevented drug induced increase in serum levels of AST, ALT, LDH, Creatinine and lipid profle (TC, LDL, VLDL and TG) and increases the levels of HDL and antioxidant parameters— SOD, GSH and CAT (in heart tissue). It also lowered the doxorubicin induced increase in heart weight due to hypertrophy. These results were also confrmed by histopathology. The results of this study strongly indicate the cardioprotective efect of fxed dose combination of BME, Flaxseed oil and CoQ10 against doxorubicin induced myocardial toxicity.
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Shoaib Shadab Iqbal,Md. Mujahid,Sayed Mohammad Kashif,Mohammad Khalid,Badruddeen,Muhammad Arif,Paramdeep Bagga,Juber Akhtar,Md. Azizur Rahman 한국한의학연구원 2016 Integrative Medicine Research Vol.5 No.4
Background Traditional systems of medicine use herbal drugs for hepatoprotection. Thus, the study was designed to evaluate the hepatoprotective and antioxidant effects of Spondias pinnata bark extracts against ethanol-induced liver injury in Wistar rats. Methods Group I animals were treated with 1 mL/kg 0.3% carboxymethyl cellulose and Group II with 12 mL/kg 50% ethanol for 8 consecutive days. Groups III–VII animals were first treated with 400 mg/kg petroleum ether extract, chloroform extract, acetone extract (AE), ethanol extract (EE), and 100 mg/kg silymarin, and then 12 mL/kg 50% ethanol orally after 2 hours pretreatment each day for 8 consecutive days. Six hours after the last dose, blood was withdrawn. The hepatoprotective activity was assessed by several biochemical and antioxidant parameters. It was accomplished by the histopathology and DNA fragmentation study of liver tissues. Results Treatment with S. pinnata extracts, mainly AE and EE significantly (p < 0.05–0.01) and dose-dependently prevented the ethanol-induced increase in serum levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, cholesterol, bilirubin, and malondialdehyde, and decrease in reduced glutathione, catalase, superoxide dismutase, and albumin. They also attenuated the ethanol-induced DNA damage. Hepatoprotective potential of the extract was less than that of standard drug silymarin. Results of the study were well supported by the histopathological observations. Conclusion S. pinnata extracts AE and EE possess a potent hepatoprotective effect against ethanol-induced liver injury in Wistar rats, and protect them from hepatotoxicity by prevention of ethanol-induced oxidative stress, DNA-damage and altered biochemical markers.
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