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Single-nozzle Core-shell Electrospun Nanofibers of PVP/Dextran as Drug Delivery System
Meera Moydeen A.,Syed Ali Padusha M.,Badr M. Thamer,Anis Ahamed N.,Abdullah M. Al-Enizi,Hany El-Hamshary,Mohamed H. El-Newehy 한국섬유공학회 2019 Fibers and polymers Vol.20 No.10
Ciprofloxacin-loaded poly(vinylpyrrolidinone) (PVP) and dextran sulfate (Dex) (PVP/Dex) nanofibers wereprepared using the emulsion electrospinning method. The physical and morphological characteristics of the preparednanofibers were evaluated by conducting a Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy(SEM) and thermogravimetric analysis (TGA). The polymer-polymer and polymer-drug interactions were determined usingdifferential scanning calorimetry (DSC). Moreover, the formation of the core-shell structure was confirmed by transmissionelectron microscopy (TEM) and confocal laser microscopy. The sustained release behavior was evaluated using ultravioletvisible(UV-vis) spectroscopy, and its kinetic mechanism was investigated using Korsmeyer-Peppas, Peppas-Sahlin, andWeibull models by a non-linear regression equation. The antibacterial properties were evaluated using the disc diffusionmethod with respect to several wound gram-positive (Methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcusepidermidis, Staphylococcus aureus, and Klebsiella pneumoniae) and gram-negative bacteria (Pseudomonas aeruginosa,Salmonella typhimurium, and Proteus vulgaris). In general, the release behavior of Ciprofloxacin from PVP/Dex is controlledby diffusion in the delivery system.