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Thakker, Shalin,Biradar, S.M.,Habbu, P.V.,Mahadevan, K.M.,Thippeswamy, B.S.,Veerapur, V.P. Kyung Hee Oriental Medicine Research Center 2010 Oriental pharmacy and experimental medicine Vol.10 No.4
The present study was undertaken to evaluate the protective effect of ethanol (EtAS), ethyl acetate (EAAS) and aqueous (AQAS) extracts of Argyreia speciosa (AS) roots against Isoproterenol (ISO)-induced myocardial infarction in rats. The animals were exposed to isoproterenol (200 mg/kg. s.c) twice at an interval of 24 hrs. Cardioprotective effect was assessed by observing ECG parameters, serum marker enzymes and histopathology of the heart. Pretreatment of EAAS, and EtAS (200 mg/kg) resulted in a significant (P < 0.001) increase in P wave, QRS complex and R-R interval, whereas heart rate, QT interval and cardiac cycle were maintained near to normal values. EtAS and EAAS showed significant (P < 0.05; P < 0.001) reduction in all the tested diagnostic markers compared to ISO treated group. Histological studies on the structural changes of heart tissue supported the protective activity of AS. The result suggest that treatment of AS prior to ISO has a significant role in protecting the animals from ISO induced myocardial infarction.
( B. K. Singhal ),( S. Chakraborti ),( Mala V. Rajan ),( T. Thippeswamy ) 한국잠사학회 2004 International Journal of Industrial Entomology Vol.8 No.1
Due to recent scientific innovations in mulberry cultivation, leaf yield has been increased manifold. However, with successive leaf harvest, a quantum drop in leaf yield and quality has been noted. This inturn has affected the silkworm rearing and farmers suffered by the frequent crop failures. This is mainly due to nutrient deficiencies in mulberry leaf. Moreover, no complete information is available about hunger signs of nutritional disorders, analytical diagnosis and critical levels of nutrients required. The present paper, thus, may serve as an important nutrient guide for identification of hunger signs, leaf nutrients status under deficiency and critical levels of the elements namely N, P, K, Ca, Mg, S, B, Cu, Fe, Mn and Zn requirements for higher leaf yield and quality. The leaf nutrient status provided may help chemist for correcting the soil status. Besides, an integration of mulberry intercropping with legumes and applications of neem and castor oil cakes, VA-mycorrhizal inoculation, biofertilizer and vermicompost are suggested as integrated nutrient management for sustainable sericulture industry. Based on the information described in this paper, a model needs to be framed for maintaining continuous supply of nutrients to obtain desired quantity and quality of mulberry leaf for successful silkworm cocoon crop and increasing overall silk productivity.
Nutritional Disorders, Analytical Diagnosis and Nutrient Guide for Mulberry, Morus indica L.
Singhal, B.K.,Chakraborti, S.,Rajan, Mala V.,Thippeswamy, T. Korean Society of Sericultural Science 2004 International Journal of Industrial Entomology Vol.8 No.1
Due to recent scientific innovations in mulberry cultivation, leaf yield has been increased manifold. However, with successive leaf harvest, a quantum drop in leaf yield and quality has been noted. This inturn has affected the silkworm rearing and farmers suffered by the frequent crop failures. This is mainly due to nutrient deficiencies in mulberry leaf. Moreover, no complete information is available about hunger signs of nutritional disorders, analytical diagnosis and critical levels of nutrients required. The present paper, thus, may serve as an important nutrient guide for identification of hunger signs, leaf nutrients status under deficiency and critical levels of the elements namely N, P, K, Ca, Mg, S, B, Cu, Fe, Mn and Zn requirements for higher leaf yield and quality. The leaf nutrient status provided may help chemist for correcting the soil status. Besides, an integration of mulberry intercropping with legumes and applications of neem and castor oil cakes, VA-mycorrhizal inoculation, biofertilizer and vermicompost are suggested as integrated nutrient management for sustainable sericulture industry. Based on the information described in this paper, a model needs to be framed for maintaining continuous supply of nutrients to obtain desired quantity and quality of mulberry leaf for successful silkworm cocoon crop and increasing overall silk productivity.
Boswellic acid suppresses cyclophosphamide induced chromosomal damage in mice
Kuntal Ganguly,N. V. Jagadeesh,Rakesh Singh,B. S. Thippeswami,Ashok D. Taranalli,Anandrao R. Kulkarni 경희대학교 융합한의과학연구소 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.3
This study was performed to determine whether Boswellic acid suppresses genotoxicity induced by cyclophosphamide in mice. Genotoxicity was induced by the administration of cyclophosphamide (50 mg/kg) in swiss albino mice and was measured by counting the number of micronuclei and observing chromosomal aberration. In test group Boswellic acid was given in the dose of 200 mg/kg and various chromosomal aberration and formation of micronuclei were observed. Boswellic acid in dose of 200 mg/kg significantly (P<0.001) inhibited the cyclophosphamide induced micronucleus formation and also significantly (P<0.001) inhibited chromosomal aberrations in mice. Whereas Boswellic acid alone did not either induce formation of micronuclei or chromosomal aberration in mice. Boswellic acid itself doesn’t have any genotoxic effect and suppresses genotoxicity induced by cyclophosphamide.
Boswellic acid suppresses cyclophosphamide induced chromosomal damage in mice
Ganguly, Kuntal,Jagadeesh, N.V.,Singh, Rakesh,Thippeswami, B.S.,Taranalli, Ashok D.,Kulkarni, Anandrao R. 경희한의학연구센터 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.3
This study was performed to determine whether Boswellic acid suppresses genotoxicity induced by cyclophosphamide in mice. Genotoxicity was induced by the administration of cyclophosphamide (50 mg/kg) in swiss albino mice and was measured by counting the number of micronuclei and observing chromosomal aberration. In test group Boswellic acid was given in the dose of 200 mg/kg and various chromosomal aberration and formation of micronuclei were observed. Boswellic acid in dose of 200 mg/kg significantly ($P$ <0.001) inhibited the cyclophosphamide induced micronucleus formation and also significantly ($P$ <0.001) inhibited chromosomal aberrations in mice. Whereas Boswellic acid alone did not either induce formation of micronuclei or chromosomal aberration in mice. Boswellic acid itself doesn't have any genotoxic effect and suppresses genotoxicity induced by cyclophosphamide.