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North Holland 2014 Nuclear Physics, Section B Vol.889 No.-
A measurement of the total pp cross section at the LHC at s=7 TeV is presented. In a special run with high-β<SUP>@?</SUP> beam optics, an integrated luminosity of 80 μb<SUP>-1</SUP> was accumulated in order to measure the differential elastic cross section as a function of the Mandelstam momentum transfer variable t. The measurement is performed with the ALFA sub-detector of ATLAS. Using a fit to the differential elastic cross section in the |t| range from 0.01 GeV<SUP>2</SUP> to 0.1 GeV<SUP>2</SUP> to extrapolate to |t|→0, the total cross section, σ<SUB>tot</SUB>(pp→X), is measured via the optical theorem to be:σ<SUB>tot</SUB>(pp→X)=95.35+/-0.38(stat.)+/-1.25(exp.)+/-0.37(extr.)mb, where the first error is statistical, the second accounts for all experimental systematic uncertainties and the last is related to uncertainties in the extrapolation to |t|→0. In addition, the slope of the elastic cross section at small |t| is determined to be B=19.73+/-0.14(stat.)+/-0.26(syst.) GeV<SUP>-2</SUP>.
Search for heavy long-lived charged particles with the ATLAS detector in pp collisions at s=7 TeV
ATLAS Collaboration,Aad, G.,Abbott, B.,Abdallah, J.,Abdelalim, A.A.,Abdesselam, A.,Abdinov, O.,Abi, B.,Abolins, M.,Abramowicz, H.,Abreu, H.,Acerbi, E.,Acharya, B.S.,Adams, D.L.,Addy, T.N.,Adelman, J. North-Holland Pub. Co 2011 Physics letters: B Vol.703 No.4
A search for long-lived charged particles reaching the muon spectrometer is performed using a data sample of 37 pb<SUP>-1</SUP> from pp collisions at s=7 TeV collected by the ATLAS detector at the LHC in 2010. No excess is observed above the estimated background. Stable τ@? sleptons are excluded at 95% CL up to a mass of 136 GeV, in GMSB models with N<SUB>5</SUB>=3, m<SUB>messenger</SUB>=250 TeV, sign(μ)=1 and tanβ=5. Electroweak production of sleptons is excluded up to a mass of 110 GeV. Gluino R-hadrons in a generic interaction model are excluded up to masses of 530 GeV to 544 GeV depending on the fraction of R-hadrons produced as g@?-balls.
Elsevier 2014 Physics letters: B Vol.737 No.-
A search for resonant WZ production in the @?ν@?<SUP>'</SUP>@?<SUP>'</SUP> (@?,@?<SUP>'</SUP>=e,μ) decay channel using 20.3 fb<SUP>-1</SUP> of s=8 TeVpp collision data collected by the ATLAS experiment at LHC is presented. No significant deviation from the Standard Model prediction is observed and upper limits on the production cross sections of WZ resonances from an extended gauge model W<SUP>'</SUP> and from a simplified model of heavy vector triplets are derived. A corresponding observed (expected) lower mass limit of 1.52 (1.49) TeV is derived for the W<SUP>'</SUP> at the 95% confidence level.
North-Holland Pub. Co 2015 Physics letters. Section B Vol.748 No.-
Measurements of the centrality and rapidity dependence of inclusive jet production in s<SUB>NN</SUB>=5.02 TeV proton-lead (p+Pb) collisions and the jet cross-section in s=2.76 TeV proton-proton collisions are presented. These quantities are measured in datasets corresponding to an integrated luminosity of 27.8 nb<SUP>-1</SUP> and 4.0 pb<SUP>-1</SUP>, respectively, recorded with the ATLAS detector at the Large Hadron Collider in 2013. The p+Pb collision centrality was characterised using the total transverse energy measured in the pseudorapidity interval -4.9<η←3.2 in the direction of the lead beam. Results are presented for the double-differential per-collision yields as a function of jet rapidity and transverse momentum (p<SUB>T</SUB>) for minimum-bias and centrality-selected p+Pb collisions, and are compared to the jet rate from the geometric expectation. The total jet yield in minimum-bias events is slightly enhanced above the expectation in a p<SUB>T</SUB>-dependent manner but is consistent with the expectation within uncertainties. The ratios of jet spectra from different centrality selections show a strong modification of jet production at all p<SUB>T</SUB> at forward rapidities and for large p<SUB>T</SUB> at mid-rapidity, which manifests as a suppression of the jet yield in central events and an enhancement in peripheral events. These effects imply that the factorisation between hard and soft processes is violated at an unexpected level in proton-nucleus collisions. Furthermore, the modifications at forward rapidities are found to be a function of the total jet energy only, implying that the violations may have a simple dependence on the hard parton-parton kinematics.
Glen Atlas,John K-J. Li,John B. Kostis 대한의용생체공학회 2014 Biomedical Engineering Letters (BMEL) Vol.4 No.3
Purpose The esophageal Doppler monitor (EDM) hastraditionally been used for minimally-invasive and continuousassessment of both cardiac output and intravascular volume. These measurements are based upon a beat-to-beat analysisof the velocity of distal thoracic aortic blood flow. Thepurpose of this paper is to compare different mathematicalmodels of LV contractile function which could utilize theEDM and subsequently be determined on a continuous basis. Methods This study investigated velocity-based contractilitymodels: peak velocity, (PV); ejection fraction, EF; meanejection fraction, ; and maximum LV radial shorteningvelocity, . Also examined are acceleration-basedmodels: mean acceleration, (MA); force, (F); the maximumrate of rise of systolic arterial blood pressure, ; andkinetic energy, (KE). Results When normalized and subsequently observed on adimensionless basis, acceleration-based models appear tohave a statistically significant greater sensitivity to changesin LV contractility. Furthermore, by combining simultaneousarterial blood pressure measurements with EDM-based flow information, the components of afterload and their effects onLV contractility could be estimated. Conclusions Future research is warranted to determine theapplicability and limitations of the EDM in continuousassessment of LV contractility and related hemodynamicparameters.
The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma
The Cancer Genome Atlas Research Network,Davis, Caleb F.,Ricketts, C.J.,Wang, M.,Yang, L.,Cherniack, Andrew D.,Shen, H.,Buhay, C.,Kang, H.,Kim, S.,Fahey, Catherine C.,Hacker, Kathryn E.,Bhanot, G.,Gor Cell Press 2014 Cancer Cell Vol.26 No.3
We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell carcinomas (ChRCCs) on the basis of multidimensional and comprehensive characterization, including mtDNA and whole-genome sequencing. The result is consistent that ChRCC originates from the distal nephron compared with other kidney cancers with more proximal origins. Combined mtDNA and gene expression analysis implicates changes in mitochondrial function as a component of the disease biology, while suggesting alternative roles for mtDNA mutations in cancers relying on oxidative phosphorylation. Genomic rearrangements lead to recurrent structural breakpoints within TERT promoter region, which correlates with highly elevated TERT expression and manifestation of kataegis, representing a mechanism of TERT upregulation in cancer distinct from previously observed amplifications and point mutations.
Genomic Classification of Cutaneous Melanoma
Cell Press ; MIT Press 2015 Cell Vol.161 No.7
We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients. We establish a framework for genomic classification into one of four subtypes based on the pattern of the most prevalent significantly mutated genes: mutant BRAF, mutant RAS, mutant NF1, and Triple-WT (wild-type). Integrative analysis reveals enrichment of KIT mutations and focal amplifications and complex structural rearrangements as a feature of the Triple-WT subtype. We found no significant outcome correlation with genomic classification, but samples assigned a transcriptomic subclass enriched for immune gene expression associated with lymphocyte infiltrate on pathology review and high LCK protein expression, a T cell marker, were associated with improved patient survival. This clinicopathological and multi-dimensional analysis suggests that the prognosis of melanoma patients with regional metastases is influenced by tumor stroma immunobiology, offering insights to further personalize therapeutic decision-making.
Venkatesh Sivaprakasam,Vartika Kulshrestha,Godlin Atlas Lawrence Livingston,Senthilnathan Arumugam 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.7
The development of lightweight, low energy and small-sized sensors incorporated with the wireless networks has brought about a phenomenal growth of Wireless Sensor Networks (WSNs) in its different fields of applications. Moreover, the routing of data is crucial in a wide number of critical applications that includes ecosystem monitoring, military and disaster management. However, the time-delay, energy imbalance and minimized network lifetime are considered as the key problems faced during the process of data transmission. Furthermore, only when the functionality of cluster head selection is available in WSNs, it is possible to improve energy and network lifetime. Besides that, the task of cluster head selection is regarded as an NP-hard optimization problem that can be effectively modelled using hybrid metaheuristic approaches. Due to this reason, an Improved Coyote Optimization Algorithm-based Clustering Technique (ICOACT) is proposed for extending the lifetime for making efficient choices for cluster heads while maintaining a consistent balance between exploitation and exploration. The issue of premature convergence and its tendency of being trapped into the local optima in the Improved Coyote Optimization Algorithm (ICOA) through the selection of center solution is used for replacing the best solution in the search space during the clustering functionality. The simulation results of the proposed ICOACT confirmed its efficiency by increasing the number of alive nodes, the total number of clusters formed with the least amount of end-to-end delay and mean packet loss rate.