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- 저자 : Arun Kumar Rajendran (검색결과 4 건)
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Arun Kumar Rajendran,Deepthi Sankar,Sivashanmugam Amirthalingam,김환,Jayakumar Rangasamy,Nathaniel S. Hwang 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Sensing the mechanical properties of the substrates or the matrix by the cells and the tissues, the subsequent downstream responses at the cellular, nuclear and epigenetic levels and the outcomes are beginning to get unraveled more recently. There have been various instances where researchers have established the underlying connection between the cellular mechanosignalling pathways and cellular physiology, cellular differentiation, and also tissue pathology. It has been now accepted that mechanosignalling, alone or in combination with classical pathways, could play a significant role in fate determination, development, and organization of cells and tissues. Furthermore, as mechanobiology is gaining traction, so do the various techniques to ponder and gain insights into the still unraveled pathways. This review would briefly discuss some of the interesting works wherein it has been shown that specific alteration of the mechanical properties of the substrates would lead to fate determination of stem cells into various differentiated cells such as osteoblasts, adipocytes, tenocytes, cardiomyocytes, and neurons, and how these properties are being utilized for the development of organoids. This review would also cover various techniques that have been developed and employed to explore the effects of mechanosignalling, including imaging of mechanosensing proteins, atomic force microscopy (AFM), quartz crystal microbalance with dissipation measurements (QCMD), traction force microscopy (TFM), microdevice arrays, Spatio-temporal image analysis, optical tweezer force measurements, mechanoscanning ion conductance microscopy (mSICM), acoustofluidic interferometric device (AID) and so forth. This review would provide insights to the researchers who work on exploiting various mechanical properties of substrates to control the cellular and tissue functions for tissue engineering and regenerative applications, and also will shed light on the advancements of various techniques that could be utilized to unravel the unknown in the field of cellular mechanobiology.
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Nanotechnology in tissue engineering and regenerative medicine
Arun Kumar Rajendran,Hwan D. Kim,Jung-whan Kim,배종우,Nathaniel S. Hwang 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.2
Nanotechnology has advanced to unparalleled heights in biomaterials science. With the clear advantage of utilizing nanotechnology based systems compared to macroscale systems, such as targeted drug delivery, triggered drug delivery, multiple payloads in nanocarriers and immune system compliance, researchers in the field of tissue engineering and regenerative medicine have utilized these to a great extent. Furthermore, with the understanding that nanoscale structures, such as nanofibers, surface topographies and other biomaterial surface features could directly alter the cellular responses, researchers are trying extensively to take advantage of these and bio mimic nature as close as possible to enhance tissue regeneration. The technical advancements in the production of these nanoscale features on a large scale, such as photolithography, has enabled researchers to incorporate these into the existing biomaterials and push forward the bench-to-bedside applications for improving the outcomes of tissue engineering and regenerative medicine. Furthermore, with the evolution of various gel systems, magnetic nanoparticle controllable systems and also the spheroid and organoid cultures, the field of tissue engineering and regenerative medicine is rapidly expanding. This brief review gives a short and basic overview about the various nanotechnological approaches that are being explored and utilized to enhance tissue regeneration.
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Pharmacognostical Evaluation of Clerodendrum viscosum (Vent.)
Richard Lobo,C. Dinesh Kumar,I. S. R. Punitha,K. Rajendran,Arun Shirwaikar,Annie Shirwaikar 한국생약학회 2006 Natural Product Sciences Vol.12 No.2
study presents a detailed pharmacognostical study of the root and leaf of the crude drugClerodendrum viscosum Vent. (Verbenaceae), an important plant in the Indian system of medicine. The root andleaf samples were studied using light and confocal microscopy, WHO recommended-physicochemicaldeterminations, and authentic phytochemical procedures. The physicochemical, morphological, and histologicalparameters presented in this paper may be proposed as parameters to establish the authenticity of C. viscosum rootand leaf, and may possibly help to diferentiate the drug from its other species.KeywordsClerodendrum viscosum, Verbenaceae, pharmacognosy, root and leaf
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