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      • SCIESCOPUSKCI등재

        The evaluation of maximum bite force in the occlusal rehabilitation of patient with Angle Class III malocclusion: a case report

        Arife Dogan,Dilek Kaymak,Duygu Karakıs 대한치과보철학회 2013 The Journal of Advanced Prosthodontics Vol.5 No.3

        The case report describes the occlusal rehabilitation of a male patient with Angle Class III malocclusion and its effect on maximum bite force. The main complaints of patient were masticatory difficulty and poor esthetic. The patient's expectations from the treatment were a good esthetic and function with a less invasive and relatively promptly way. Therefore, increasing of the occlusal vertical dimension (OVD) and then restoring the maxillary and mandibular teeth was chosen by the patient among the treatment options. At the beginning of treatment maximum bite force of patient was measured. Then an occlusal splint was provided to evaluate the adaptation of the patient to the altered OVD. Full mouth rehabilitation with metal ceramic restorations was made. After the completion of full mouth restoration, bite force measurement was repeated and patient exhibited increased maximum bite force. Full mouth restorative treatment in a patient with Class III malocclusion could be an effective treatment approach to resolve esthetic concern and to improve masticatory function related to maximum bite force.

      • KCI등재

        A Study on Strengthening of Reinforced Concrete Frames using Precast Concrete Panels

        Arife Akin,Rifat Sezer 대한토목학회 2016 KSCE JOURNAL OF CIVIL ENGINEERING Vol.20 No.6

        This study describes the effectiveness of the behavior resulting from strengthening infill walls in existing reinforced concrete frame systems with low resistance against earthquake effects using precast concrete panels. In this study, a strengthening method that can be applied without building occupants having to leave the building was investigated. For this purpose, six 1/2 scale, two-story and single span test specimens with brick infill walls and low earthquake resistance, which have common errors seen in existing reinforced concrete buildings, were generated. The first of test frames with equivalent properties was tested as the reference specimen under reversible repeatable lateral loads. Others were tested after high-strength concrete panels produced in different geometric shapes were strengthened by bonding them onto existing frame infill walls. Brick infill walls strengthened using concrete panels were modeled as shell elements by SAP2000 software package and the accuracy of experimental studies were compared with analytical results. Experimental and analytical studies demonstrated that the reinforcement method significantly improved properties, such as resistance to lateral loads, energy dissipation capacity, of brick infill reinforced concrete frames.

      • Patients with HER2-positive Early Breast Cancer Receiving Adjuvant Trastuzumab: Clinicopathological Features, Efficacy, and Factors Affecting Survival

        Ulas, Arife,Kos, Tugba,Avci, Nilufer,Cubukcu, Erdem,Olmez, Omer Fatih,Bulut, Nilufer,Degirmenci, Mustafa Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4

        Background: The aim of the present study was to evaluate clinicopathological characteristics of our early stage breast cancer patients who are epidermal growth factor receptor 2 (HER2) overexpressed/amplified (HER2+), the efficacy of trastuzumab treatment and survival results. Materials and Methods: Patients with HER2-positive early stage breast cancer receiving adjuvant trastuzumab were investigated retrospectively. Clinicopathological features of 210 patients and treatment outcome were analysed. To evaluate survival rates, the Kaplan-Meier method was used. Univariate and multivariate analyses were conducted with the Cox regression model. Results: Mean age of the patients was 51.8, 71.9% being postmenopausal. Some 37.6% of patients were node negative, and 31% had T1 tumor size and 52.4% were positive for estrogen receptor. Of 210 patients, 89.5% completed planned 52 weeks adjuvant trastuzumab treatment. The median follow up was 27.5 months (6.0-86.0). Relapse free survival (RFS) was 68.0 months (95% CI: 62.1-74.0) and overall survival (OS) was 74.8 months (95% CI: 69.5-80.1). The 3 year OS for all patients was 92.0% and RFS was 79.6%. During follow up, relapse was detected at the rate of 14.3%. Trastuzumab associated cardiotoxicity was found at the rate of 3.3%. In univariate analyses, larger tumor size and grade III were significantly associated (p<0.05) with RFS. Multivariate analyses of covariates displaying p<0.05 identified grade III as an independent prognostic factor. Conclusions: In the present study, it was established that trastuzumab had a satisfactory safety profile and treatment efficacy as in other clinical studies and that among clinicopathological factors evaluated, only being grade 3 had a significant effect on RFS. The occurrence of relapse with adjuvant trastuzumab makes it necessary to identify molecular predictors, which will define this group better and help explain resistance to anti HER2 based therapies.

      • Medication Errors in Chemotherapy Preparation and Administration: a Survey Conducted among Oncology Nurses in Turkey

        Ulas, Arife,Silay, Kamile,Akinci, Sema,Dede, Didem Sener,Akinci, Muhammed Bulent,Sendur, Mehmet Ali Nahit,Cubukcu, Erdem,Coskun, Hasan Senol,Degirmenci, Mustafa,Utkan, Gungor,Ozdemir, Nuriye,Isikdogan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5

        Background: Medication errors in oncology may cause severe clinical problems due to low therapeutic indices and high toxicity of chemotherapeutic agents. We aimed to investigate unintentional medication errors and underlying factors during chemotherapy preparation and administration based on a systematic survey conducted to reflect oncology nurses experience. Materials and Methods: This study was conducted in 18 adult chemotherapy units with volunteer participation of 206 nurses. A survey developed by primary investigators and medication errors (MAEs) defined preventable errors during prescription of medication, ordering, preparation or administration. The survey consisted of 4 parts: demographic features of nurses; workload of chemotherapy units; errors and their estimated monthly number during chemotherapy preparation and administration; and evaluation of the possible factors responsible from ME. The survey was conducted by face to face interview and data analyses were performed with descriptive statistics. Chi-square or Fisher exact tests were used for a comparative analysis of categorical data. Results: Some 83.4% of the 210 nurses reported one or more than one error during chemotherapy preparation and administration. Prescribing or ordering wrong doses by physicians (65.7%) and noncompliance with administration sequences during chemotherapy administration (50.5%) were the most common errors. The most common estimated average monthly error was not following the administration sequence of the chemotherapeutic agents (4.1 times/month, range 1-20). The most important underlying reasons for medication errors were heavy workload (49.7%) and insufficient number of staff (36.5%). Conclusions: Our findings suggest that the probability of medication error is very high during chemotherapy preparation and administration, the most common involving prescribing and ordering errors. Further studies must address the strategies to minimize medication error in chemotherapy receiving patients, determine sufficient protective measures and establishing multistep control mechanisms.

      • Lung Cancer in Women, a Different Disease: Survival Differences by Sex in Turkey

        Ulas, Arife,Tokluoglu, Saadet,Kos, Mehmet,Silay, Kamile,Akinci, Sema,Oksuzoglu, Berna,Alkis, Necati Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2

        Purpose: In this study, we aimed to evaluate the effects of sex-based non-small cell lung cancer (NSCLC) varieties on survival rates. Materials and Methods: A retrospective study was performed in patients with NSCLC who were diagnosed by histological methods between the years 2000 and 2010. A chi-square test was used to compare variables. Overall survival (OS) was estimated by the Kaplan-Meier method. Results: Of the 844 patients, 117 (13.9%) were women and 727 (86.1%) were men. Adenocarcinoma was more common in women than in men (p<0.0001). There were more women non-smokers than men (p<0.0001). There was no statistically significant difference in ECOG PS, weight loss>10%, stage, LDH, albumin and treatment between women and men. Women younger than 65 years (17.0 vs 12.0 months; p=0.03), who had adenocarcinoma histology (15.0 vs 10.0 months; p=0.006) and who had a hemoglobin level ${\geq}12g/dL$ (18.0 vs 12.0 months; p=0.01) were found to have a better median OS rate than men. Median OS rates were found to be 13.0 months in females and 12.0 months in males (p=0.14). Among metastatic patients, the median OS was 11.0 months in females and 8.0 months in males (p=0.005). Among stage IIIB and stage IV patients who had first line platinum-based chemotherapy, the median OS was 17.0 months in women and 11.0 months in men (p=0.002). The response rate of chemotherapy was higher in women than in men (p=0.03). Conclusions: In our study, we found that survival duration is longer and chemotherapy response is better in women with NSCLC who do not have anemia or comorbidities and who are mostly non-smokers with adenocarcinomas. Further studies regarding the causes of these differences may provide clarity on this subject.

      • KCI등재

        Development of body formulations using colemanite waste in porcelain tile production

        Nezahat Ediz,Arife Yurdakul 한양대학교 세라믹연구소 2009 Journal of Ceramic Processing Research Vol.10 No.6

        Porcelain tiles have become one of the most important products of the ceramic industry in the last decade mainly owing to their attractive physical and mechanical properties including high strength, high fracture toughness and density, excellent chemical resistance and low water absorption. The attractiveness of using porcelain has initiated intensive research work for alternative raw materials because of the depletion and the high cost of the usual materials currently used in the ceramic industry. In this research, the aim was to use boron-bearing solid wastes (Ca2B6O11.5H2O) as an alternative fluxing agent to Na-feldspar (NaAlSi3O8) in fast-fired porcelain tile bodies produced under industrial conditions without altering the microstructural, physical and chemical properties required from the final product. For this purpose, the suitability of the colemanite-added porcelain tile bodies to fast-firing conditions was determined using an optical dilatometer. It was then understood that a calcination process was needed in order to effectively use the waste in porcelain tile production. Therefore, the calcination process was applied to the colemanite solid waste before the waste-added bodies were sintered at 1210℃ and 1130℃. The results were compared with those of the standard porcelain tile bodies produced at the same sintering temperatures. After detailed phase analysis (XRD), microstructural examination (SEM-EDX) and physical-mechanical tests, it was found that the standard porcelain tile body produced at 1210℃ (R1) could be obtained at 1130℃ by adding 5% colemanite solid waste (by weight) to the standard tile body to replace Na-feldspar (R7). This result enables production of porcelain tiles at lower temperatures without changing the other operational parameters, only using colemanite waste as a new fluxing agent in the body formulations. Porcelain tiles have become one of the most important products of the ceramic industry in the last decade mainly owing to their attractive physical and mechanical properties including high strength, high fracture toughness and density, excellent chemical resistance and low water absorption. The attractiveness of using porcelain has initiated intensive research work for alternative raw materials because of the depletion and the high cost of the usual materials currently used in the ceramic industry. In this research, the aim was to use boron-bearing solid wastes (Ca2B6O11.5H2O) as an alternative fluxing agent to Na-feldspar (NaAlSi3O8) in fast-fired porcelain tile bodies produced under industrial conditions without altering the microstructural, physical and chemical properties required from the final product. For this purpose, the suitability of the colemanite-added porcelain tile bodies to fast-firing conditions was determined using an optical dilatometer. It was then understood that a calcination process was needed in order to effectively use the waste in porcelain tile production. Therefore, the calcination process was applied to the colemanite solid waste before the waste-added bodies were sintered at 1210℃ and 1130℃. The results were compared with those of the standard porcelain tile bodies produced at the same sintering temperatures. After detailed phase analysis (XRD), microstructural examination (SEM-EDX) and physical-mechanical tests, it was found that the standard porcelain tile body produced at 1210℃ (R1) could be obtained at 1130℃ by adding 5% colemanite solid waste (by weight) to the standard tile body to replace Na-feldspar (R7). This result enables production of porcelain tiles at lower temperatures without changing the other operational parameters, only using colemanite waste as a new fluxing agent in the body formulations.

      • KCI등재

        Characterization of porcelain tile bodies with colemanite waste added as a new sintering agent

        Nezahat Ediz,Arife Yurdakulb 한양대학교 세라믹연구소 2009 Journal of Ceramic Processing Research Vol.10 No.4

        This research investigated the possible use of high boron oxide (B2O3) bearing solid waste, obtained during the enrichment of colemanite mineral (Ca2B6O11.5H2O), as an alternative sintering agent to Na-feldspar (NaAlSi3O8) in porcelain tile production. The chemical composition, mineralogical properties and behaviour under the heat treatment of solid colemanite waste were characterized in detail by the use of inductive coupled plasma (ICP), X-ray diffraction (XRD) and differential thermal analysis (DTA) / thermo-gravimetric analysis (TG). Physical-mechanical properties of standard and waste-added porcelain tile bodies obtained by sintering at 1210℃ (under factory conditions) such as green strength, dry strength, fired strength and water absorption were determined as a function of waste replacement for Na-feldspar. The sintering behaviour of waste-added porcelain tile bodies under fast firing conditions was also determined by an optical dilatometer and compared with that of standard porcelain tiles. The phases obtained in standard and waste-added porcelain tile bodies after sintering were determined by XRD analysis. The effect of these phases on microstructure and the relationships between physical-mechanical properties and the microstructure were also investigated through a scanning electron microscope (SEM) and energy dispersive X-ray (EDX) spectrometery. After detailed phase studies and microstructural analysis together with the characterization of behaviour under heat treatment, it was discovered that colemanite waste had a high fluxing character and decreased the sintering temperature when used in porcelain tile recipes to replace Na-feldspar. It was also determined that factories using colemanite waste should work at lower sintering temperatures in order to obtain better physical-mechanical properties for porcelain tiles and to reduce energy costs. This research investigated the possible use of high boron oxide (B2O3) bearing solid waste, obtained during the enrichment of colemanite mineral (Ca2B6O11.5H2O), as an alternative sintering agent to Na-feldspar (NaAlSi3O8) in porcelain tile production. The chemical composition, mineralogical properties and behaviour under the heat treatment of solid colemanite waste were characterized in detail by the use of inductive coupled plasma (ICP), X-ray diffraction (XRD) and differential thermal analysis (DTA) / thermo-gravimetric analysis (TG). Physical-mechanical properties of standard and waste-added porcelain tile bodies obtained by sintering at 1210℃ (under factory conditions) such as green strength, dry strength, fired strength and water absorption were determined as a function of waste replacement for Na-feldspar. The sintering behaviour of waste-added porcelain tile bodies under fast firing conditions was also determined by an optical dilatometer and compared with that of standard porcelain tiles. The phases obtained in standard and waste-added porcelain tile bodies after sintering were determined by XRD analysis. The effect of these phases on microstructure and the relationships between physical-mechanical properties and the microstructure were also investigated through a scanning electron microscope (SEM) and energy dispersive X-ray (EDX) spectrometery. After detailed phase studies and microstructural analysis together with the characterization of behaviour under heat treatment, it was discovered that colemanite waste had a high fluxing character and decreased the sintering temperature when used in porcelain tile recipes to replace Na-feldspar. It was also determined that factories using colemanite waste should work at lower sintering temperatures in order to obtain better physical-mechanical properties for porcelain tiles and to reduce energy costs.

      • SCIESCOPUSKCI등재

        Evaluation of the effect of two different occlusal splints on maximum occlusal force in patients with sleep bruxism : a pilot study

        Duygu Karakis,Arife Dogan,Bulent Bek 대한치과보철학회 2014 The Journal of Advanced Prosthodontics Vol.6 No.2

        PURPOSE. The occlusal splint has been used for many years as an effective treatment of sleep bruxism. Several methods have been used to evaluate efficiency of the occlusal splints. However, the effect of the occlusal splints on occlusal force has not been clarified sufficiently. The purpose of this study was to evaluate the effect of occlusal splints on maximum occlusal force in patients with sleep bruxism and compare two type of splints that are Bruxogard-soft splint and canine protected hard stabilization splint. MATERIALS AND METHODS. Twelve students with sleep bruxism were participated in the present study. All participants used two different occlusal splints during sleep for 6 weeks. Maximum occlusal force was measured with two miniature strain-gage transducers before, 3 and 6 weeks after insertion of occlusal splints. Clinical examination of temporomandibular disorders was performed for all individuals according to the Craniomandibular Index (CMI) before and 6 weeks after the insertion of splints. The changes in mean occlusal force before, 3 and 6 weeks after insertion of both splints were analysed with paired sample t-test. The Wilcoxon test was used for the comparison of the CMI values before and 6 weeks after the insertion of splints. RESULTS. Participants using stabilization splints showed no statistically significant changes in occlusal force before, 3, and 6 weeks after insertion of splint (P>.05) and participants using Bruxogard-soft splint had statistically significant decreased occlusal force 6 weeks after insertion of splint (P<.05). There was statistically significant improvement in the CMI value of the participants in both of the splint groups (P<.05). CONCLUSION. Participants who used Bruxogard-soft splint showed decreases in occlusal force 6 weeks after insertion of splint. The use of both splints led to a significant reduction in the clinical symptoms.

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