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        Endoscopic Self-Expandable Metal Stent Placement for Malignant Afferent Loop Obstruction After Pancreaticoduodenectomy: A Case Series and Review

        Arata Sakai,Hideyuki Shiomi,Takao Iemoto,Ryota Nakano,Takuya Ikegawa,Takashi Kobayashi,Atsuhiro Masuda,Yuzo Kodama 대한소화기내시경학회 2020 Clinical Endoscopy Vol.53 No.4

        In this study, we assessed a series of our cases in which endoscopic self-expandable metal stents (SEMSs) were used to treat malignantafferent loop obstruction (ALO) that arose after pancreaticoduodenectomy (PD). We retrospectively examined the records of 7 patientswho underwent endoscopic SEMS placement for malignant ALO following PD. Clinical success was achieved in all cases. The medianprocedure time was 30 min (range, 15–50 min). There were no cases of stent occlusion, and no procedure-related adverse events wereencountered. All patients died of their primary disease, and the median overall survival period was 155 days (range, 96–374 days). Are-intervention involving endoscopic ultrasound-guided hepaticogastrostomy combined with antegrade stenting was performed forobstructive jaundice and acute cholangitis in 1 case. In conclusion, endoscopic SEMS placement may be an effective and safe treatmentfor malignant ALO that arises after PD.

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        Endoscopic Ultrasound-Guided Gastroenterostomy for Afferent Loop Syndrome

        Hideyuki Shiomi,Arata Sakai,Ryota Nakano,Shogo Ota,Takashi Kobayashi,Atsuhiro Masuda,Hiroko Iijima 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.6

        Afferent loop syndrome (ALS) is a mechanical obstruction of the afferent limbs after gastrectomy with gastrojejunostomyreconstruction. Patients with cancer recurrence require immediate and less invasive treatment because of their poor condition. Percutaneous transhepatic/transluminal drainage (PTD) and endoscopic enteral stenting offer reasonable palliative treatment formalignant ALS but are not fully satisfactory in terms of patient quality of life (QoL) and stent patency. Endoscopic ultrasound-guidedgastroenterostomy (EUS-GE) using a lumen-apposing metal stent may address these shortcomings. Clinical data from 11 reportsshowed that all patients who had undergone EUS-GE had positive technical and clinical outcomes. The adverse event rate was11.4%, including only mild or moderate abdominal pain, with no severe adverse events. Indirect comparative studies indicated thatpatients who had undergone EUS-GE had a significantly superior QoL, a higher clinical success rate, and a lower reintervention ratethan those who had undergone PTD or endoscopic enteral stenting. Although the evidence is limited, EUS-GE may be consideredas a first-line treatment for malignant ALS because it has better clinical outcomes than other less invasive treatments, such as PTD orendoscopic enteral stenting. Further prospective randomized control trials are necessary to establish EUS-GE as a standard treatmentfor ALS.

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