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Anum Sahar,Shaukat Ali 한국섬유공학회 2018 Fibers and polymers Vol.19 No.11
Two new hetrofunctional triazine based UV absorbers (1a, 2a) were theoretically and experimentally synthesized at our previous work. In the current investigation, these absorbers were applied to woven cotton fabric via the exhaust method of dyeing, that increase the ultraviolet protection factor of fabric by keeping the quantity of finishing chemicals low to combat with the environmental problem. Therefore, a statistical tool central composite rotatable design (CCRD) of response surface methodology (RSM) was selected for process modeling. The CCRD was applied to study the effect of three process variables (salt, alkali and temperature) on the two responses (exhaustion and fixation percentage) and for the evaluation of the interactive effects of the three process variables. The results show that the applied quadratic model was highly significant and fit to the experimental data for both the UV absorbers (1a and 2a). The values of optimized parameters for CCRD, in cotton finishing with newly synthesized UV absorbers (1a and 2a) were respectively as follows; temperature of 61.91 oC, dose of salt 34.28 g/l and dose of alkali 19.82 g/l. Under these conditions, 77.56 (±3) and 76.08 (±3) exhaustion and 81.12 (±3) and 79.23 (±3) fixation percentage obtained for UV absorbers 1a and 2a respectively. The ultraviolet protection factor (UPF) of treated cotton fabric under optimized conditions appeared in very good range. The results reveal that the applied statistical design economically and effectively predicts the optimized conditions of finishing of cotton by keeping the number of experiments low than the one factor at a time method, that ultimately reduce water pollution and wastage of resources.
Reasons for Patient's Delay in Diagnosis of Breast Carcinoma in Pakistan
Memon, Zahid Ali,Shaikh, Anum Nizamuddin,Rizwan, Sundus,Sardar, Maimoona Batool Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Background: Delay in diagnosis of breast cancer is associated with a poorer survival and a pivotal contribution to this delayed diagnosis comes from patient delay in presenting at a clinic. Reasons involved must be evaluated in order to decrease this reducible delay. Objectives: i) To evaluate the reasons for patient delay in diagnosis of breast cancer; ii) to investigate any association with other variables. Materials and Methods: A 6 month cross sectional study (from July 2012 to Dec 2012), was carried out in Surgical and Oncology Units of Civil Hospital, Karachi. A total of 100 females diagnosed with breast cancer of any histological type were interviewed after informed consent and relevant data were collected. Due ethical clearance was obtained. Results: Mean age was $47.5{\pm}12.1$ years with a range from 25-77 years. Mean duration of delay was $5.13{\pm}4.8$ months, from shortest 1 month to longest 36 months. Duration of delay was observed to be no delay (<1 month) in 28%, short delay (1-3 months) in 30% and long delay (>3 months) in 42% of patients. Considering the symptoms as "harmless" (39%) was the most frequent reason of delay followed by "temporary" (20%) and the "use of traditional methods" (12%). Most common reason for later approaches was an increase in the size of the lump (41%). Statistically significant association (p-value <0.05) of longer patient delay was obtained with being single, being illiterate, painless breast lump as the first symptom, negative family history of breast cancer and vague attribution of the symptoms. Conclusions: Significant delay in approach to health care facility was observed in our study due to variable reasons given by women. Sufficient awareness regarding breast cancer, its symptoms and favorable effects of a timely diagnosis on prognosis must be imparted to our general population.
Bhatti, Abu Bakar Hafeez,Waheed, Anum,Hafeez, Aqsa,Akbar, Ali,Syed, Aamir Ali,Khattak, Shahid,Kazmi, Ather Saeed Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.7
Background: Distance from anal verge and abdominoperineal resection are risk factors for circumferential resection margin (CRM) positivity in rectal cancer. Induction chemotherapy (IC) before concurrent chemoradiation (CRT) has emerged as a new treatment modification. Impact of IC before concurrent CRT on CRM positivity in low rectal cancer remains to be independently studied. The objective of this study was to determine CRM positivity in low rectal cancer, with and without prior IC, and to identify predictors of disease free and overall survival. Materials and Methods: Patients who underwent surgery for rectal cancer between 2005 and 2011 were retrospectively reviewed and divided into two groups. Group 1 received IC before CRT and Group 2 did not. Demographics, clinicopathological variables and CRM status were compared. Actuarial 5 year disease free survival (DFS), overall survival (OS) and independent predictors of survival were determined. Results: Patients in the IC group presented with advanced stage (Stage 3=89.2% versus 75.4%) (P=0.02) but a high rate of total mesorectal excision (TME) (100% versus 93.4%) (P=0.01) and sphincter preservation surgery (54.9 % versus 22.9%) (P=0.001). Patients with low rectal cancer who received IC had a significantly low positive CRM rate (9.2% versus 34%) (P=0.002). Actuarial 5 year DFS in IC and no IC groups were 39% and 43% (P=0.9) and 5 year OS were 70% and 47% (P=0.003). Pathological tumor size [HR: 2.2, CI: 1.1-4.5, P=0.01] and nodal involvement [HR: 2, CI: 1.08-4, P=0.02] were independent predictors of relapse while pathological nodal involvement [HR: 2.6, CI: 1.3-4.9, P=0.003] and IC [HR: 0.7, CI: 0.5-0.9, P=0.02] were independent predictors of death. Conclusions: In low rectal cancer, induction chemotherapy before CRT may significantly decrease CRM positivity and improve 5 year overall survival.