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RISS 인기검색어
- 검색키워드
- 저자 : António G. Castro (검색결과 2 건)
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Eco-Friendly Manufacturing of Nano-TiO2 Coated Cotton Textile with Multifunctional Properties
Mirele Horsth de Paiva Teixeira,Luís Antônio Lourenço,Wagner Artifon,Celso Junior de Castro Vieira,Sergio Yesid Gómez González,Dachamir Hotza 한국섬유공학회 2020 Fibers and polymers Vol.21 No.1
In this work, multifunctional cotton fabrics were developed by immobilizing TiO2 nanoparticles (TiO2-NPs) usingan eco-friendly bath through a highly-scalable technique. The effects of TiO2-NPs, cross-linking agent, catalyst and curingtemperatures were assessed by analysis of variance and surface response methodology. The results disclose an excellentperformance of treated textiles for various applications: flame-retardant (char content enhanced by 1000 %), photocatalyticdecontamination (>90 % of contaminant abatement and feasibility for multiple reuses), self-cleaning of intense stains (up to80 % of stain vanishing), bacterial inhibition without TiO2 UV-activation (≈25 % of bacteria growth reduction). Moreover,those properties were durable for at least five domestic laundering cycles.
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Daniel B. Rodrigues,Helena R. Moreira,Mariana T. Cerqueira,Alexandra P. Marques,António G. Castro,Rui L. Reis,Rogério P. Pirraco 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4
Background: T cell priming has been shown to be a powerful immunotherapeutic approach for cancer treatment in terms of efficacy and relatively weak side effects. Systems that optimize the stimulation of T cells to improve therapeutic efficacy are therefore in constant demand. A way to achieve this is through artificial antigen presenting cells that are complexes between vehicles and key molecules that target relevant T cell subpopulations, eliciting antigenspecific T cell priming. In such T cell activator systems, the vehicles chosen to deliver and present the key molecules to the targeted cell populations are of extreme importance. In this work, a new platform for the creation of T cell activator systems based on highly tailorable nanoparticles made from the natural polymer gellan gum (GG) was developed and validated. Methods: GG nanoparticles were produced by a water in oil emulsion procedure, and characterized by dynamic light scattering, high resolution scanning electronic microscopy and water uptake. Their biocompatibility with cultured cells was assessed by a metabolic activity assay. Surface functionalization was performed with anti-CD3/CD28 antibodies via EDC/NHS or NeutrAvidin/Biotin linkage. Functionalized particles were tested for their capacity to stimulate CD4+ T cells and trigger T cell cytotoxic responses. Results: Nanoparticles were approximately 150 nm in size, with a stable structure and no detectable cytotoxicity. Water uptake originated a weight gain of up to 3200%. The functional antibodies did efficiently bind to the nanoparticles, as confirmed by SDS-PAGE, which then targeted the desired CD4+ populations, as confirmed by confocal microscopy. The developed system presented a more sustained T cell activation over time when compared to commercial alternatives. Concurrently, the expression of higher levels of key cytotoxic pathway molecules granzyme B/perforin was induced, suggesting a greater cytotoxic potential for future application in adoptive cancer therapy. Conclusions: Our results show that GG nanoparticles were successfully used as a highly tailorable T cell activator system platform capable of T cell expansion and re-education.
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