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Mechanism of Weight Gain in Kidney Transplantation Recipients
Young Eun Cho,Cashion Ann 계명대학교 간호과학연구소 2016 계명간호과학 Vol.19 No.3
Purpose: Weight gain after kidney transplantation is one of the common complications, which might lead to co-morbid conditions including hypertension and diabetes. It is closely related to early graft loss, unfavorable long-term outcomes and poor survival rate. In this paper, we discussed various factors which might induce weight gain after kidney transplant. Methods: The impact of demographic factors, immunosuppressants, nutrition and physical activity, psychosocial factors and genomic factors in weight gain after kidney transplant is reviewed. Results: Factors related to weight gain post-transplant include demographic features (race and gender), immunosuppressants, unbalanced nutrition intake and decreased physical activity, depression and low socioeconomic status, and highly expressed obesity-related genes. However, study results vary depending on the characteristics of the study population, duration of the observation post-transplant and analysis method. Conclusion: Many factors related to weight gain after kidney transplant are modifiable. Therefore, prior to transplantation and during the post-transplant period, clinicians should consider all these factors to provide appropriate interventions to prevent weight gain.
Cho Young-Eun,Lee Hyangkyu,Kim Hyungsuk,Yun Sijung,Cashion Ann 한국기초간호학회 2020 Journal of korean biological nursing science Vol.22 No.2
Purpose: Weight gain after kidney transplantation is a critical factor that can lead to poor outcomes with cardiovascular complications. Many studies have been conducted to identify predictive markers of future weight changes at the time of transplant. Recently, circulating exosomes and its contents including miRNAs and proteins have attracted attention as potential biomarkers. In this pilot study, we investigated exosomal proteins and weight change after kidney transplant. Methods: Recipients (n=10) were classified into two groups; weight gainers (n=5, 9.7±4.4kg) and weight losers (n=5, -6.4±1.8kg) based on their weight changes at 12-months posttransplant. Based on the exosomal protein profiles obtained by the LC-MS/MS, differentially expressed proteins were identified between the groups. Results: Concentration and the mean size of exosomes significantly increased at 12-months compared to the baseline (p=.009) in the total group. Eleven exosomal proteins were found at the baseline as differentially expressed between the two groups. In the weight gain group, complement proteins including HV169, C3, C4B, and C4A, were significantly upregulated. Conclusion: Our pilot study suggests that exosomal complementary proteins are associated with weight gain after kidney transplantation. Further studies are needed to clarify the role of these exosomal proteins in the underlying mechanisms of weight changes in kidney transplant recipients.