http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Andrea R. Levine, M.D., M.S. (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Subphenotypes of Acute Respiratory Distress Syndrome: Advancing towards Precision Medicine
Andrea R. Levine, M.D., M.S.,Carolyn S. Calfee, M.D., M.A.S. 대한결핵및호흡기학회 2024 Tuberculosis and Respiratory Diseases Vol.87 No.1
Acute respiratory distress syndrome (ARDS) is a common cause of severe hypoxemiadefined by the acute onset of bilateral non-cardiogenic pulmonary edema. The diagnosisis made by defined consensus criteria. Supportive care, including prevention offurther injury to the lungs, is the only treatment that conclusively improves outcomes. The inability to find more advanced therapies is due, in part, to the highly sensitive butrelatively non-specific current syndromic consensus criteria, combining a heterogenouspopulation of patients under the umbrella of ARDS. With few effective therapies,the morality rate remains 30% to 40%. Many subphenotypes of ARDS have been proposedto cluster patients with shared combinations of observable or measurable traits. Subphenotyping patients is a strategy to overcome heterogeneity to advance clinicalresearch and eventually identify treatable traits. Subphenotypes of ARDS have beenproposed based on radiographic patterns, protein biomarkers, transcriptomics, and/ormachine-based clustering of clinical and biological variables. Some of these strategieshave been reproducible across patient cohorts, but at present all have practical limitationsto their implementation. Furthermore, there is no agreement on which strategy isthe most appropriate. This review will discuss the current strategies for subphenotypingpatients with ARDS, including the strengths and limitations, and the future directionsof ARDS subphenotyping.
ScienceON
KISS연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
