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        Outcomes of Direct Infrapectineal Buttress Plate for Quadrilateral Surface Fractures of Acetabulum Using an Anterior Intrapelvic Approach

        ( Umair Nadeem ),( Irfan Qadir ),( Jahanzeb Mazari ),( Atiq Uz Zaman ),( Amer Aziz ) 대한고관절학회 2021 Hip and Pelvis Vol.33 No.1

        Purpose: Reduction and stable fixation of the quadrilateral plate are challenging primarily due to its location in the true pelvis, limited bone stock, juxta-articular nature, and its comminution. The current study aimed to investigate the quality of reduction and functional outcomes after open reduction and internal fixation (ORIF) with infrapectineal buttress plating of the quadrilateral surface via an anterior intrapelvic approach. Materials and Methods: We conducted a retrospective review of twenty-one patients with acetabular fractures involving quadrilateral plate operated at Ghurki Trust Teaching Hospital between January 2017 and December 2018. Radiological assessment of the quality of reduction was conducted using criteria described by Matta. Functional outcomes were evaluated using a modified Postel Merle d’Aubigné score. Results: The current study included 15 males and 6 females with a mean age of 40.67±12.17 years (range, 22- 62 years). The most common fracture pattern was anterior column and posterior hemi-transverse in eight patients followed by true bicolumn and T-type fractures in seven and four patients respectively. Both transverse fractures were transtectal. The quality of reduction according to Matta criteria was anatomical in 14 patients, imperfect in five and poor in two. Functional outcomes were excellent in 47.6% cases, good in 42.9%, and fair in 9.5% cases. Both patients with fair outcomes had non-anatomical reduction, and one required total hip arthroplasty at a later time. Conclusion: Quadrilateral plate reconstruction with an infrapectineal buttress plate applied though an anterior intrapelvic approach provides high rates of anatomical reduction and yields good functional outcomes.

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        A review of carbon-based materials and their coating techniques for biomedical implants applications

        Hassan Sadia,Nadeem Aroosa Younis,Qaiser Hafsah,Kashif Amer Sohail,Ahmed Ammad,Khan Khushbukhat,Altaf Amna 한국탄소학회 2023 Carbon Letters Vol.33 No.4

        Carbon-based materials have emerged as an excellent class of biomedical materials due to their exceptional mechanical properties, lower surface friction, and resistance to wear, tear, and corrosion. Experimental studies have shown the promising results of carbon-based coatings in the field of biomedical implants. The reasons for their successful applications are their ability to suppress thrombo-inflammatory reactions which are evoked as an immune response due to foreign body object implantation. Different types of carbon coatings such as diamond-like carbon, pyrolytic carbon, silicon carbide, and graphene have been extensively studied and utilized in various fields of life including the biomedical industry. Their atomic arrangement and structural properties give rise to unique features which make them suitable for multiple applications. Due to the specificity and hardness of carbon-based precursors, only a specific type of coating technique may be utilized for nanostructure development and fabrication. In this paper, different coating techniques are discussed which were selected based on the substrate material, the type of implant, and the thickness of coating layer. Chemical vapor deposition-based techniques, thermal spray coating, pulsed laser deposition, and biomimetic coatings are some of the most common techniques that are used in the field of biomaterials to deposit a coating layer on the implant. Literature gathered in this review has significance in the field of biomedical implant industry to reduce its failure rate by making surfaces inert, decreasing corrosion related issues and enhancing biocompatibility.

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        Can the bone marrow harvest volume be reduced safely in hematopoietic stem cell transplantation with pediatric sibling donors?

        Awatif AlAnazi,Amer Nadeem,Khawar Siddiqui,Ali AlAhmari,Ibrahim Ghemlas,Abdullah AlJefri,Hawazen AlSaedi,Saadiya Khan,Mouhab Ayas 대한혈액학회 2023 Blood Research Vol.58 No.1

        Background Reduced harvest volumes in pediatric donors appear to have the potential to reduce donor- associated risks while maintaining engraftment in recipients; however, the allowable harvest volume reduction remains undefined. Methods We retrospectively analyzed the data pairs of 553 bone marrow (BM) harvests from pediatric (age at harvest <18 yr) sibling donors and clinical outcomes of 553 pediatric (age at infusion <14 yr) transplant-naïve recipients to assess the optimal BM harvest volume needed from pediatric donors to obtain the desired CD34+ cell count (≥3.0×106 cells per kg of recipient weight), and to study its impact on the clinical outcomes of transplantation in pediatric recipients. Results The minimum desired CD34+ cell count of ≥3.0×106 per kg of recipient weight was achieved for 506 (95.3%) of donor-recipient pairs. The median CD34+ cell yield was 6.4×106 per kg of recipient weight (range, 1.2‒33.8×106) in donors younger than 5 years old at harvest, 4.7×106 (range, 0.3‒28.5×106) in donors aged 5‒10 years and 2.1×106 (range, 0.3‒11.3×106) in donors older than 10 years (P <0.001). Conclusion The infused CD34+ cell dose (×106 cells/kg of recipient weight) had no impact on GRFS; however, a CD34+ cell dose of >7×106 cells/kg of recipient weight did not improve hematopoietic recovery.

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