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Yazmín Hernández‑Díaz,Thelma Beatriz González‑Castro,Isela Esther Juárez‑Rojop,Carlos Alfonso Tovilla‑Zárate,María Lilia López‑Narváez,Alma Delia Genis‑Mendoza,Ana Fresan,Humberto Nicolini 한국유전학회 2021 Genes & Genomics Vol.43 No.11
Background Several studies have evaluated the possible association between polymorphisms or variants in Corticotropinreleasing hormone 1 receptor gene (CRHR1) with depression; however, results remain contradictory and heterogeneous. Objective To our knowledge, we conducted the frst comprehensive systematic review and meta-analysis evaluating the association of the CRHR1 gene and the risk of depression. Methods A search online was conducted in databases for any CRHR1 genetic association studies in depression. Data were extracted for evaluation of pooled estimates using meta-analytic techniques. Statistical analyses were performed using the Comprehensive Meta-analysis, v2.0 software. Result A total of 1403 cases and 2353 mentally healthy controls were included in this study. We found a signifcant association of rs242941, rs1876828 and rs242939 variants of the CRHR1 gene with depression. No association of CRHR1 rs110402 and depression was observed. Conclusion Our meta-analysis shows that some variants of the CRHR1 gene (rs242941, rs1876828 and rs242939) might confer susceptibility to depression. Further studies with larger sample sizes need to be conducted.