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      • Assessment of Relationship between Wilms' Tumor Gene (WT1) Expression in Peripheral Blood of Acute Leukemia Patients and Serum IL-12 and C3 Levels

        Rezai, Omran,Khodadadi, Ali,Heike, Yuji,Mostafai, Ali,Gerdabi, Nader Dashti,Rashno, Mohammad,Abdoli, Zahra Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16

        Background: Leukemia is a common cancer among children and adolescents. Wilms' tumor gene (WT1) is highly expressed in patients with acute leukemia. It is found as a tumor associated antigen (TAA) in various types of hematopoietic malignancies and can be employed as a useful marker for targeted immunotherapy and monitoring of minimal residual disease (MRD). In this regard, WT1 is a transcription factor that promotes gene activation or repression depending on cellular and promoter context. The purpose of this study was assessment of WT1 gene expression in patients with acute leukemia, measurement of IL-12 and C3 levels in serum and evaluation of the relationship between them. Materials and Methods: We evaluated the expression of WT1 mRNA using real-time quantitative RT-PCR and serum levels of IL-12 and C3 using ELISA and nephelometry in peripheral blood of 12 newly diagnosed patients with acute leukemia and 12 controls. Results: The results of our study showed that the average wT1 gene expression in patients was 7.7 times higher than in healthy controls (P <0.05). In addition, IL-12 (P = 0.003) and C3 (P <0.0001) were significantly decreased in the test group compared to controls. Conclusions: WT1 expression levels are significantly higher in patients compared with control subjects whereas serum levels of interleukin-12 and C3 are significantly lower in patients. Wt1 expression levels in patients are inversely related with serum levels of IL-12 and C3.

      • SCOPUSKCI등재

        Adsorption of crystal violet dye by agricultural rice bran waste: Isotherms, kinetics, modeling and influencing factors

        Mojtaba Rezazadeh,Majid Baghdadi,Naser Mehrdadi,Mohammad Ali Abdoli 대한환경공학회 2021 Environmental Engineering Research Vol.26 No.3

        In this study, the potential of modified rice bran (MRB) was investigated for the elimination of crystal violet (CV) from plotted effluent. In this regard, rice bran (RB) was modified by chlorosulfonic acid. The results of FTIR, EDX, and SEM analysis showed structural change, an increase in the amount of sulfur, and the formation of a new band (998 and 1,225 ㎝<SUP>-1</SUP>) in MRB, respectively. The impact of different variables such as contact time, MRB dosage, pH, CV concentration, and ions content on removal efficiency was studied by using batch experiments. In addition, response surface methodology was employed to optimize the experiments. The maximum removal efficiency of 97.4% was obtained at the adsorbent dosage of 2 g L<SUP>-1</SUP>, initial CV concentration of 100 ㎎ L<SUP>-1</SUP>, and contact time of 42.75 min. The highest adsorption capacity of 603 ㎎ g-1 was acquired by the Langmuir model. The best description of kinetic data was achieved by the Elovich model. The thermodynamic study of the adsorption indicated an endothermic and spontaneous reaction. MRB could be regenerated by HCl 0.5 ㏖ L<SUP>-1</SUP> and removal efficiency was declined 10 percent after 5 adsorption/desorption cycles. It was concluded that MRB is an operational adsorbent to remove CV from effluents.

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        The Effect of Soft and Rigid Cervical Collars on Head and Neck Immobilization in Healthy Subjects

        Kourosh Barati,Mokhtar Arazpour,Roshanak Vameghi,Ali Abdoli,Farzad Farmani 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.3

        Study Design: Whiplash injury is a prevalent and often destructive injury of the cervical column, which can lead to serious neck pain. Many approaches have been suggested for the treatment of whiplash injury, including anti-inflammatory drugs, manipulation, supervised exercise, and cervical collars. Cervical collars are generally divided into two groups: soft and rigid collars. Purpose: The present study aimed to compare the effect of soft and rigid cervical collars on immobilizing head and neck motion. Overview of Literature: Many studies have investigated the effect of collars on neck motion. Rigid collars have been shown to provide more immobilization in the sagittal and transverse planes compared with soft collars. However, according to some studies, soft and rigid collars provide the same range of motion in the frontal plane. Methods: Twenty-nine healthy subjects aged 18–26 participated in this study. Data were collected using a three-dimensional motion analysis system and six infrared cameras. Eight markers, weighing 4.4 g and thickened 2 cm2 were used to record kinematic data. According to the normality of the data, a paired t -test was used for statistical analyses. The level of significance was set at α=0.01. Results: All motion significantly decreased when subjects used soft collars (p <0.01). According to the obtained data, flexion and lateral rotation experienced the maximum (39%) and minimum (11%) immobilization in all six motions using soft collars. Rigid collars caused maximum immobilization in flexion (59%) and minimum immobilization in the lateral rotation (18%) and limited all motion much more than the soft collar. Conclusions: This study showed that different cervical collars have different effects on neck motion. Rigid and soft cervical collars used in the present study limited the neck motion in both directions. Rigid collars contributed to significantly more immobilization in all directions.

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        Chemical modification of polystyrene foam using functionalized chitosan with dithiocarbamate as an adsorbent for mercury removal from aqueous solutions

        Babak Porkar,Pourya Alipour Atmianlu,Mahyar Mahdavi,Majid Baghdadi,Hamidreza Farimaniraad,Mohammad Ali Abdoli 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.4

        One of the major environmental issues today is waste pollution, particularly non-biodegradable wastes such as polystyrene waste. Furthermore, heavy metal contamination is a major environmental threat. Mercury is one of the most hazardous and poisonous contaminants, and its usage in various industrial processes has resulted in contaminated effluents being released into surface runoff and groundwater. Because of the beneficial physical properties of polystyrene foam, this non-biodegradable waste was used in this study as a suitable medium for chemical modification. The polystyrene foam was first modified using crosslinked chitosan, and then it was reacted with carbon disulfide to improve its performance for the removal of Hg2+. The prepared composite was used for the removal of mercury ions from contaminated water. The adsorbent’s physical, chemical, and morphological properties were determined using energy-dispersive spectroscopy (EDS), Fourier-transform infrared spectroscopy (FT-IR), Field emission scanning electron microscopy (FE-SEM), and Brauer-Emmett-Teller (BET) analyses. Specific surface area, porosity, and average pore diameter were determined to be 314.8 m2/g, 0.345 cm2/g, and 1.96 nm, respectively. Experiments were designed to investigate the effects of pH, contact time, and contaminant concentration by the Box-Behnken response surface methodology. The maximum removal percentage of 79.85% was achieved for the initial mercury concentration of 50 mg/L at pH 4. Moreover, the adsorption was observed to follow the Dubinin-Radushkevich isotherm. Studies on adsorbent recovery also showed that the adsorbent can be recovered and reused for at least three cycles.

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