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- 저자 : Al-Khalidi, Hisham (검색결과 3 건)
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Prakash Kuppuswamy,Saeed QY Al Khalidi,Nithya Rekha Sivakumar International Journal of Computer ScienceNetwork S 2024 International journal of computer science and netw Vol.24 No.1
The security of data and information using encryption algorithms is becoming increasingly important in today's world of digital data transmission over unsecured wired and wireless communication channels. Hybrid encryption techniques combine both symmetric and asymmetric encryption methods and provide more security than public or private key encryption models. Currently, there are many techniques on the market that use a combination of cryptographic algorithms and claim to provide higher data security. Many hybrid algorithms have failed to satisfy customers in securing data and cannot prevent all types of security threats. To improve the security of digital data, it is essential to develop novel and resilient security systems as it is inevitable in the digital era. The proposed hybrid algorithm is a combination of the well-known RSA algorithm and a simple symmetric key (SSK) algorithm. The aim of this study is to develop a better encryption method using RSA and a newly proposed symmetric SSK algorithm. We believe that the proposed hybrid cryptographic algorithm provides more security and privacy.
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Sadiya Aziz Anah,Saad Aziz Anah,Khadeeja Abees Hmood Al-Khalidy 대한수의학회 2022 大韓獸醫學會誌 Vol.62 No.4
In the study, zinc oxide nanoparticles (ZNOPs) at concentrations of 20, 40, and 60 mg/kg were tested for their antimicrobial action against the oocysts of Eimeria tenella. The oocysts of E. tenella were isolated from the feces of broilers received at the veterinary hospital in Diwaniyah Province and initially diagnosed by compound optical microscopy. The oocysts were confirmed molecularly by polymerase chain reaction targeting the ITS1 gene with a molecular weight of 409 bp. The results in the first week showed that ZNOP concentrations of 20 and 40 mg/kg possess various activities against E. tenella, while 60 mg/kg was the most effective in reducing excreted oocysts compared to the positive control and amprolium group, along with the appearance of mild symptoms and a mortality rate of 0.8%. In the second week of infection, excreted oocysts and mortality rates generally decreased in all treated groups. A comparison of all groups showed that the 60 mg/kg ZNOP-treated group had a significantly lower number of excreted oocysts, and all birds in this group recovered during the second week of infection. These findings revealed the prospect of using ZNOPs against E. tenella in challenging situations of the appearance of resistance to anticoccidial agents.
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Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer
Joung, Je-Gun,Oh, Bo Young,Hong, Hye Kyung,Al-Khalidi, Hisham,Al-Alem, Faisal,Lee, Hae-Ock,Bae, Joon Seol,Kim, Jinho,Cha, Hong-Ui,Alotaibi, Maram,Cho, Yong Beom,Hassanain, Mazen,Park, Woong-Yang,Lee, American Association for Cancer Research 2017 Clinical Cancer research Vol.23 No.23
<P><B>Purpose:</B> Tumors continuously evolve to maintain growth; secondary mutations facilitate this process, resulting in high tumor heterogeneity. In this study, we compared mutations in paired primary and metastatic colorectal cancer tumor samples to determine whether tumor heterogeneity can predict tumor metastasis.</P><P><B>Experimental Design:</B> Somatic variations in 46 pairs of matched primary-liver metastatic tumors and 42 primary tumors without metastasis were analyzed by whole-exome sequencing. Tumor clonality was estimated from single-nucleotide and copy-number variations. The correlation between clinical parameters of patients and clonal heterogeneity in liver metastasis was evaluated.</P><P><B>Results:</B> Tumor heterogeneity across colorectal cancer samples was highly variable; however, a high degree of tumor heterogeneity was associated with a worse disease-free survival. Highly heterogeneous primary colorectal cancer was correlated with a higher rate of liver metastasis. Recurrent somatic mutations in <I>APC, TP53</I>, and <I>KRAS</I> were frequently detected in highly heterogeneous colorectal cancer. The variant allele frequency of these mutations was high, while somatic mutations in other genes such as <I>PIK3CA</I> and <I>NOTCH1</I> were low. The number and distribution of primary colorectal cancer subclones were preserved in metastatic tumors.</P><P><B>Conclusions:</B> Heterogeneity of primary colorectal cancer tumors can predict the potential for liver metastasis and thus, clinical outcome of patients. <I>Clin Cancer Res; 23(23); 7209–16. ©2017 AACR</I>.</P>
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