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- 저자 : Akanksha Tyagi (검색결과 11 건)
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Akanksha Tyagi,Deog-Hwan Oh 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
In the present study, low molecular weight peptides (≤8KDa) were identified using liquid chromatography-electrospray ionization quantitative time-of-flight mass spectrometry from L. reuteri fermented brown rice samples. In L. reuteri fermented brown rice sample, various peptides were identified but six peptides were selected and synthesized based on their abundance in the LC-MS/MS analysis and literature study. The peptides namely P1, P2, P3, P4, P5 and P6 showed strong scavenging IC50 values against DPPH (5.4±0.6-14±1 μg/ml), ABTS (20±1.5-87.5±1.5 μg/ml), FRAP (28±1-87.5±0.5 μg/ml) and PSC (28.1±0.5-148±0.7 μg/ml) radicals respectively. Moreover, the cell antioxidant assay (CAA) also showed significant (81.10±0.9-309.47±2.7 μg/ml) cytoprotective effects against H₂O₂-induced cellular oxidative damage. As per our knowledge, all of the six peptides were not identified before so this study is the first report to identify and confirm their antioxidant ability against different radicals.
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Nam-Hyeon Kim,Akanksha Tyagi,Su-Jung Yeon,Deog-Hwan Oh 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
In this study, Limosilactobacillus reuteri generated the highest levels of GABA after fermentation. To ascertain whether germination can improve the GABA levels of brown rice, raw brown rice (Raw), germinated brown rice (Germ), fermented brown rice (Ferm) and fermented-germinated brown rice (G+F) were compared. Then, antioxidant activities were investigated for all the samples. In Ferm BR, DPPH (114.40±0.66), ABTS (130.52±0.97) and FRAP (111.16±1.83) mg Trolox equivalent 100g, dry weight (DW), were observed as the highest among all samples. Total phenolic content (97.13±0.59) and total flavonoids contents (79.62±1.33) mg GAE/100 g and catechin equivalent/100 g, DW, were also found to be highest in fermented BR. Further, phytochemical profiling using UHPLC-Q-TOF MS/MS and cell antioxidant assay revealed L. reuteri fermented BR as a strong antioxidant with the abundance of bioactive compounds, such as GABA, tryptophan, coumaric acid, L-ascorbic acid, linoleic acid, β-carotenol, eugenol, 6-gingerol, etc., as well as bioactive peptides which could contribute to the health-promoting properties of L. reuteri fermented brown rice.
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Ramachandran Chelliah,Chae-Rin Park,Nam-Hyeon Kim,Akanksha Tyagi,Deog-Hwan Oh 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
In the present study, the Fructooligosaccharide was obtained by enzymatic treatment of banana peel extract and purified. In addition, the growth enhancement of probiotics strains was analyzed. Further, the targeting the microbiota-gut-brain axis, and reverse the impact of chronic Stress in Mice. Based on the in-vitro results, the banana peel crude extract and standard FOS showed similar growth enhancement was observed. Further, the crude BPE were purified using HPLC–ELSD indicating 24.9 mg/g of crude BPE showed similar structural characterization (HPLC, FTIR) with commercial FOS. Anxiety stress reduction was confirmed in Mice fed with BPE and FOS product, based on behavior pattern study (Open field, elevated position, and elevated position test), blood chemistry, and microbiota analysis using metagenome sequencing. The optimal mixing percentage of BPE and oligosaccharide cookies and muffins determined to be 5.00% and 46% had significant effects on color, taste, texture, flavor, and overall quality and sensory scores (p<0.01). In conclusion, the in-vitro and in-vivo results indicate that the extracted prebiotics reduced the stress.
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Role of Peptides in Antiviral (COVID-19) Therapy
Chelliah, Ramachandran,Daliri, Eric Banan-Mwine,Elahi, Fazle,Yeon, Su-Jung,Tyagi, Akanksha,Park, Chae Rin,Kim, Eun Ji,Jo, kyoung Hee,Oh, Deog-Hwan The Korean Society of Food Hygiene and Safety 2021 한국식품위생안전성학회지 Vol.36 No.5
COVID-19와 같은 전염병 감염 시나리오 전반에 걸쳐 펩타이드 기반 치료법을 발견하고 설계하는 개발 시대의 추세는 보다 효율적이고 저렴한 치료 환경으로 발전할 수 있습니다. 결과적으로, 그들의 단백질 분해 약화는 천연펩타이드 약물의 단점 중 하나입니다. 펩티도미메틱스는 이 단점을 해결하는 데 도움이 될 수 있습니다. 이 리뷰에서 펩타이드 및 펩타이드 기반 약물 발견은 숙주 안지오텐신 전환 효소-2(ACE2) 수용체 및 바이러스 스파이크 (S)단백질의 연관성을 포함하는 중증 코로나바이러스 폐색전 증후군(SARS-CoV-2)의 주요 진입 기전 중 하나를 표적으로 요약했습니다. 또한, 펩타이드 기반의 새로운 치료법을 통해 COVID-19에 대해 연구된 단백질, 펩타이드 및 기타 가능한 조치의 이점을 다룹니다. 그리고 펩타이드 기반 약물 치료 환경의 개요는 진화적 관점, 구조적 특성, 작동 한계값 및 치료 영역에 대한 설명으로 구성된다 Trends in the developing era to discover and design peptide-based treatments throughout an epidemic infection scenario such as COVID-19 could progress into a more efficient and low-cost therapeutic environment. However, the weakening of proteolysis is one downside of natural peptide drugs. But, peptidomimetics may help resolve this issue. In this review, peptide and peptide-based drug discovery were summarized to target one key entry mechanism of severe coronavirus pulmonary emboli syndrome (SARS-CoV-2), which encompasses the association of the host angiotensin-converting enzyme-2 (ACE2) receptor and viral spike (S) protein. Furthermore, the benefits of proteins, peptides and other possible actions that have been studied for COVID-19 through new peptide-based treatments are discussed in the review. Lastly, an overview of the peptide-based drug therapy environment is comprised of an evolutionary viewpoint, structural properties, operational thresholds, and an explanation of the therapeutic area.
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