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- 저자 : Ajay Uprety (검색결과 1 건)
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Blood-brain barrier dysfunction as a potential therapeutic target for neurodegenerative disorders
Ajay Uprety,Yeji Kang,김수영 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.5
The blood-brain barrier (BBB) is composed ofspecifi c tight junction proteins and transporters expressed onthe lining of endothelial cells of the vasculature in the brain. The structural and functional integrity of the BBB is one ofthe most critical factors for maintaining brain homeostasisand is mainly regulated by complex interactions betweenvarious cell types, such as endothelial cells, pericytes, andastrocytes, which are shaped by their diff erential responsesto changes in microenvironments. Alterations in these cellularcomponents have been implicated in neurodegenerativedisorders. Although it has long been considered thatBBB dysfunction is a mere ramifi cation of pathologicalphenomena, emerging evidence supports its critical role inthe pathogenesis of various disorders. In epilepsy, heightenedBBB permeability has been found to be associated withincreased occurrence of spontaneous seizures. Additionally,exaggerated infl ammatory responses signifi cantly correlatewith increased BBB permeability during healthy aging. Furthermore,it has been previously reported that BBB disruptioncan be an early marker for predicting cognitive impairmentin the progression of Alzheimer’s disease. We hereinreview a potential role of the major cellular components ofthe BBB, with a focus on the contribution of BBB disruption,in neurodegenerative disease progression.
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