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RISS 인기검색어
- 검색키워드
- 저자 : Adu-Sarkodie, Yaw (검색결과 2 건)
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Jeon, Hyon Jin,Pak, Gi Deok,Im, Justin,Owusu-Dabo, Ellis,Adu-Sarkodie, Yaw,Gassama Sow, Amy,Bassiahi Soura, Abdramane,Gasmelseed, Nagla,Keddy, Karen H,Bjerregaard-Andersen, Morten,Konings, Frank,Aseff Oxford University Press 2018 Clinical infectious diseases Vol.67 No.12
<▼1><P><B>Abstract</B></P><P><B>Background</B></P><P>The World Health Organization recently prequalified a typhoid conjugate vaccine (TCV), recommending its use in persons ≥6 months to 45 years residing in typhoid fever (TF)–endemic areas. We now need to consider how TCVs can have the greatest impact in the most vulnerable populations.</P><P><B>Methods</B></P><P>The Typhoid Fever Surveillance in Africa Program (TSAP) was a blood culture-based surveillance of febrile patients from defined populations presenting at healthcare facilities in 10 African countries. TF and invasive non-typhoidal <I>Salmonella</I> (iNTS) disease incidences were estimated for 0–10 year-olds in one-year age increments.</P><P><B>Results</B></P><P><I>Salmonella</I> Typhi and iNTS were the most frequently isolated pathogens; 135 and 94 cases were identified, respectively. Analysis from three countries was excluded (incomplete person-years of observation (PYO) data). Thirty-seven of 123 TF cases (30.1%) and 71/90 iNTS disease cases (78.9%) occurred in children aged <5 years. No TF and 8/90 iNTS infections (8.9%) were observed in infants aged <9 months. The TF incidences (/100 000 PYO) for children aged <1 year and 1 to <2 years were 5 and 39, respectively; the highest incidence was 304 per 100 000 PYO in 4 to <5 year-olds. The iNTS disease incidence in the defined age groups ranged between 81 and 233 per 100 000 PYO, highest in 1 to <2 year-olds. TF and iNTS disease incidences were higher in West Africa.</P><P><B>Conclusions</B></P><P>High burden of TF detected in young children strengthens the need for TCV introduction. Given the concurrent iNTS disease burden, development of a trivalent vaccine against <I>S.</I> Typhi, <I>S.</I> Typhimurium, and <I>S.</I> Enteritidis may be timely in this region.</P></▼1><▼2><P>A significant burden of typhoid fever in children aged <5 years in sub-Saharan Africa merits the introduction of typhoid conjugate vaccine at age 9 months, which coincides with the first dose of measles vaccine.</P></▼2>
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Frickmann, Hagen,Dekker, Denise,Boahen, Kennedy,Acquah, Samuel,Sarpong, Nimako,Adu-Sarkodie, Yaw,Schwarz, Norbert G.,May, Jü,rgen,Marks, Florian,Poppert, Sven,Wiemer, Dorothea F.,Hagen, Ralf M. Informa Healthcare 2013 Scandinavian journal of infectious diseases Vol.45 No.8
<P><I>Background:</I> Invasive enteropathogenic bacteria can cause systemic infections. Data from studies with PCR detection suggest, at least for Salmonella enterica, that blood culture may lead to underestimation in the tropics. Corresponding data are lacking for other invasive enteropathogenic bacteria. We compared classical blood culture and molecular methods for the diagnosis of blood infections. <I>Methods:</I> A real-time multiplex PCR for Salmonella spp., Shigella spp./entero- invasive Escherichia coli (EIEC), Yersinia spp., and Campylobacter jejuni was applied to 2321 retained blood culture samples from Ghanaian patients, after enrichment by automated culture. <I>Results:</I> PCR detected Salmonella DNA in 56 out of 58 pre-incubated Ghanaian blood cultures with growth of S. enterica. In 2 samples molecular diagnosis was only possible after 1:10 dilution. Twenty-two samples negative by blood culture and 1 positive with Micrococcus spp. were PCR-positive for Salmonella spp. In addition, 3 Shigella spp./EIEC, 2 Yersinia spp., and 1 C. jejuni were detected by PCR but not by culture growth. <I>Conclusions:</I> Real-time PCR was more sensitive in identifying invasive enteropathogenic bacteria than automated blood culture, which is hampered by a lack of evidence-based standardization of pre-analytic conditions in the tropics. Primary agar culture and Gram-staining prior to automated blood culture is advisable in cases where transportation times are long.</P>
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