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RISS 인기검색어
- 검색키워드
- 저자 : Adolfo Saá (검색결과 2 건)
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Comparative Analysis of Sustainable Cooling Systems in Intermittent Turning of Magnesium Pieces
Eva María Rubio,María Villeta,Diego Carou,Adolfo Saá 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.
Cutting fluids have been widely used in machining processes because of their favourable lubrication and cooling properties. However,their high costs, the risk to worker’s health and environmental concerns have necessitated the development of alternative methods ofcooling and lubricating that eliminate or, reduce such drawbacks. In this study, a comparative analysis of two sustainable coolingsystems (dry machining and minimum quantity lubrication (MQL) system) in intermittent turning of UNS M11917 magnesium pieceswas performed. To analyse the influence of the cooling system on intermittent cutting, the surface roughness was selected as theresponse variable. In addition to the cooling system, other parameters such as the feed rate, spindle speed, tool type, interruption typeand measurement zone (defined by the length and the generatrix) were taken into account. A combined L4x32 experimental design withthree nested replications was carried out. The obtained data were analysed using the analysis of variance (ANOVA) method. Mainconclusions include the identification of the feed rate and interruption type as the most important sources of surface roughnessvariability. In addition, it is possible to affirm that, in general, increases in the coolant flow rate, within the range studied, lead toslightly poorer surface roughness results.
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Use of Reverse Genetics to Enhance the Oncolytic Properties of Newcastle Disease Virus
Vigil, Adam,Park, Man-Seong,Martinez, Osvaldo,Chua, Mark A.,Xiao, Sa,Cros, Jerome F.,Martí,nez-Sobrido, Luis,Woo, Savio L.C.,Garcí,a-Sastre, Adolfo American Association for Cancer Research 2007 Cancer research Vol.67 No.17
<P>Naturally occurring strains of Newcastle disease virus (NDV) have shown oncolytic therapeutic efficacy in preclinical studies and are currently in clinical trials. Here, we have evaluated the possibility to enhance the cancer therapeutic potential of NDV by means of reverse genetics. Mice bearing s.c. implanted CT26 tumors were treated with intratumoral (i.t.) injections of a recombinant NDV modified to contain a highly fusogenic F protein. These treated mice exhibited significant reduction in tumor development compared with mice treated with the unmodified virus. Furthermore, mice in a CT26 metastatic tumor model treated with an i.v. injection of the genetically engineered NDV exhibited prolonged survival compared with wild-type control virus. In addition, we examined whether the oncolytic properties of NDV could be improved by expression of immunostimulatory molecules. In this regard, we engineered several NDVs to express granulocyte macrophage colony-stimulating factor, IFN-gamma, interleukin 2 (IL-2), or tumor necrosis factor alpha, and evaluated their therapeutic potential in an immunocompetent colon carcinoma tumor model. Mice bearing s.c. CT26 tumors treated with i.t. injections of recombinant NDV expressing IL-2 showed dramatic reductions in tumor growth, with a majority of the mice undergoing complete and long-lasting remission. Our data show the use of reverse genetics to develop enhanced recombinant NDV vectors as effective therapeutic agents for cancer treatment.</P>
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