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폐경 여성에서의 호르몬 대체요법에 따른 유방 음영과의 연관성에 대한 연구
박한뫼(Han Moie Park),문혜성(Hye Sung Moon),정혜원(Hye Won Jung),류호선(Ho Sun Lyoo),김무희(Moo Hee Kim),최혜영(Hye Young Choi),황아실이(A Sil Ee Hwaung),안정자(Jung Ja Ahn) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11
Objective : To determine the frequency and degree on change in mammographic densities, and calcification in the breast tissue, during different types of hormone replacement therapy and to evaluate the factors that play a role on the breast cancer. Method : A retrospective review of 268 cases menopausal women for HRT group and 52 cases menopausal women for unmatched control group. Mammographic evaluations for the distribution of breast densities and calcification, new solid mass and cyst in four different type of HRT were performed each every year during 5 years. The significant increase of breast densities and calcifications and new formation of neoplasm were taken with breast sonogram. 10 cases were biopsied for the confirmation of maliganancy. Result : Compared with the conrol groups, the hormone user group have a significant increase in the breast densitiy for 5 years (p<0.05), and the addition of progesterone in HRT showed a significant increase in the breast densities during 5 years (p<0.05), but we cannot find the correlation for new formation of solid mass and cyst and HRT (p>0.05). Among 10 cases in suspicious malignancy, 9 cases were confirmed to the malignancy by biopsy. Conclusion : The results of this study revealed that not only progesterone combined HRT but also estrogen only HRT significantly increased mammographic density. There is no relationship on the calcification and HRT in this study. The annual checking of mammography is necessary to HRT.
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