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RISS 인기검색어
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- 저자 : 홍석호 ( Seock Ho Hong ) (검색결과 2 건)
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장인석 ( In Seok Jang ),박준범 ( Jun Beom Park ),홍석호 ( Seock Ho Hong ),김정훈 ( Jeong Hoon Kim ),김창진 ( Chang Jin Kim ),이정교 ( Jung Kyo Lee ) 대한뇌종양학회 2005 대한뇌종양학회지 Vol.4 No.2
Objective￡ºMalignant meningioma constitutes a rare subset of meningiomas and it is difficult to manage them. There has been continuing debate on the subject of malignant meningioma, but few studies of large series have been reported. We studied the local control and survival rates of patients with this aggressive meningioma. Method￡ºPathologically proven 28 malignant meningioma patients were retrospectively reviewed. Surgical specimens were re-examined blindly by neuropathologist without any patient information, and the diagnosis of malignant meningiomas was based on the 2000 World Health Organization classification of tumors of the nervous system. Extent of surgical resection was determined according to Simpson`s classification by reviewing the chart and postoperative scan if possible. Various factors concerning outcome were analyzed. Results￡ºTen(35.7%) had local recurrence during the follow-up, of which 7(35.0%) of 20 complete excisions and 3 (37.5%) of 8 incomplete excisions. The overall 3-, 5-, and 10-year local control rates were 67.0%, 62.3%, and 54.5%, respectively. Eight(28.6%) died during follow-up period. The overall 3-, 5-, and 10-year survival rates were 77.0%, 72.8%, and 63.7%, respectively. The extent of surgical excision was one of the important significant prognostic factors not for local control but for survival(p=0.3020 and 0.0314, respectively). Extracranial metastasis was not seen in our cases. Conclusion￡ºComplete surgical excision was the most important factor in improving survival. We consider that the administration of adjuvant radiotherapy following initial resection is crucial to long-term control. Careful long-term follow-up is mandatory because malignant meningioma shows a broad range of aggressiveness and natural history.
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기초 : 뇌수막종의 악성도 및 예후에 대한 종양억제유전자 메틸화의 역할
조지영 ( Ji Young Cho ),김정훈 ( Jeong Hoon Kim ),홍석호 ( Seock Ho Hong ),김창진 ( Chang Jin Kim ),이정교 ( Jung Kyo Lee ) 대한뇌종양학회 2007 대한뇌종양학회지 Vol.6 No.2
Objective:Aberrant methylation of CpG islands in promoter of human genes is known as an alternative mechanism of gene silencing that contributes to tumorigenesis in various human tumors. DNA methylation status of tumor suppressor genes (TSGs) is poorly understood in meningiomas, so we performed this study to determine the roles for DNA methylation on the meningioma grades and outcome. Methods:We have examined the methylation status of 5 TSGs in 81 human meningiomas(59 Grade I, 15 Grade II, and 7 Grade III) by methylation specific polymerase chain reaction(PCR). Results:Five TSGs showed different profile of methylation status:46.9% for p16, 21.0% for p14, 42.0% for RB1, 7.4% for RASSF1A, and 42.0% for E-cadherin. DNA hypermethylation frequencies in p16, p14, RASSF1A, and E-cadherin were higher in Grade II than in Grade I and Grade III except RB1. There were no correlations of the methylation status of these TSGs with meningioma grades. Also, the methylation status of all TSGs was not associated with recurrence and survival. Conclusion:Our results suggest that DNA methylation may be one of the important events in tumorigenesis of meningiomas and it may be a major molecular mechanism especially for Grade II meningiomas. The methylation status of TSGs is not useful to discriminate among histologic grades and outcome of meningiomas. Further molecular studies will be needed to predict the malignancy and biological behavior of meningiomas.
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