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      • SCOPUSKCI등재

        대장암에서 림프절 침범과 암의 침윤도가 예후에 미치는 영향

        최윤미 ( Yun Mee Choi ),김해성 ( Hae Sung Kim ),최선근 ( Sun Keun Choi ),허윤석 ( Yun Seok Hur ),이건영 ( Kun Yong Lee ),김세중 ( Sei Joong Kim ),안승익 ( Seung Ick Ahn ),홍기천 ( Kee Cheun Hong ),신석환 ( Seok Hwan Shin ),우제홍 대한소화기학회 2002 대한소화기학회지 Vol.40 No.6

        Background/Aims: This study was carried out to evaluate prognostic significance of the clinicopathological features in colorectal cancer. Methods: The records of 413 patients who underwent a curative resection of colorectal cancer from June of 1996 to December of 2000 were examined focusing on the clinicopathological factors and difference of survival rates. Results: The numbers of lymph node metastasis were significantly related to age, depth of invasion, histologic differentiation, tumor size, lymphovascular invasion, perineural invasion, and preoperative serum CEA level. In the univariate analysis for 366 patients, the depth of invasion (p=0.0017), histologic differentiation (p=0.0069), lymph node metastasis (p=0.0000), lymphovascular invasion (p=0.0001), perineural invasion (p=0.0008), and preoperative serum CEA level (p=0.0005) turned out to be significant prognostic factors. The histologic differentiation between the primary lesion and the metastatic lymph node was the same in 90.7% of the studied cases. Capsular invasion was found in 92 cases (53.5%), but there was no significant difference in survival rates between the capsular invasion group and non-capsular invasion group (p=0.0510). Conclusions: In this study, the depth of invasion, lymph node metastasis, and the number of lymph node metastasis could be recognized as important prognostic factors for colorectal cancer. However, further follow-up studies are needed to determine the role of the various clinical and pathological factors in colorectal cancer prognosis. (Korean J Gastroenterol 2002;40:371-378)

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