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각막 상피 재건을 위한 콜라겐 겔 압축 공정 기반의 하이브리드 콜라겐 시트 제작
홍현준(Hyeonjun Hong),허만일(Man-Il Huh),김홍균(Hong-Kyun Kim),김동성(Dong Sung Kim) 대한기계학회 2015 대한기계학회 춘추학술대회 Vol.2015 No.11
Limbal stem cell deficiency is one of a critical corneal disease which is accompanied by recurrent epithelial defects, corneal vascularization and conjunctivalisation, resulting in a blindness. Many research groups tried to develop a tissueengineered substrate for carrying limbal epithelial cells to regenerate the corneal epithelium. However, in vitro construction of tissue-engineered cell carrier is limited in materials to satisfy both mechanically stable and biologically compatible properties. In this regard, this study firstly suggest hybrid collagen sheet and its fabrication process to overcome the drawback. The hybrid collagen sheet can be successfully developed through integrating reconstituted type I collagen and decellularized corneal lenticule based on adequate collagen compression system and process.