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갈근강황추출물의 갱년기 증상 개선에 대한 유효성 및 안전성 평가
안하영 ( Ha-young Ahn ),허다희 ( Da-hee Hur ),김용재 ( Yong-jae Kim ),차민석 ( Min-seok Cha ),이동녕 ( Dong-nyung Lee ),김형준 ( Hyeong-jun Kim ) 대한한방부인과학회 2020 大韓韓方婦人科學會誌 Vol.33 No.4
Objectives: This clinical trial is performed to investigate the effect of improving the menopausal symptoms and the safety of extract obtained from Pueraria thunbergiana Bentham and Curcuma longa L. in menopausal women Methods: This study was randomized, double blinded, placebo-controlled clinical trial. 110 women with menopausal symptoms were assigned to treatment group (n=55) and control group (n=55). The results of this study were evaluated through changes in Kupperman Index score, Menopause-specific Quality of Life Questionnaire (MENQOL) score, degree of hot flashes and sweating, Body Mass Index(BMI), laboratory test results including female hormones. Results: In the treatment group compared to before baseline, there was significant difference in the Kupperman Index total score, score of each item in the Kupperman Index, MENQOL total score, hot flush and sweating visual analogue scale (VAS), hot flush score, and hot flush duration at one time. However, there was also a significant change compared to baseline in the control group, there was no significant difference between the treatment group and the control group. There was no significant change in female hormone levels in both group, and there were no adverse events associated with the clinical trial product. Conclusions: This clinical trial showed that extract obtained from Pueraria thunbergiana Bentham and Curcuma longa L. was helpful in improving menopausal symptoms in menopausal women without significant side effects.
대한한방부인과학회지에 게재된 체계적 문헌고찰의 방법론 및 보고의 질 평가
서지혜 ( Ji-hye Seo ),강소현 ( So-hyeon Kang ),허다희 ( Da-hee Hur ),이동녕 ( Dong-nyung Lee ),김형준 ( Hyeong-jun Kim ) 대한한방부인과학회 2021 大韓韓方婦人科學會誌 Vol.34 No.2
Objectives: The purpose of this study is to assess the methodological and reporting quality of the systematic reviews in the Journal of Korean obstetrics and gynecology. Methods: Systematic reviews in the Journal of Korean obstetrics and gynecology were selected from January 1987 to February 2021, by searching Koreanstudies Information Service System (KISS) and the search system of the Society of Korean medicine obstetrics and gynecology. The methodological and reporting quality was assessed using A MeaSurement Tool to Assess systematic Reviews 2 (AMSTAR 2) tool and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. Results: Total of 19 systematic reviews were finally included for this study. The levels of methodological quality were low in 63.2% and very low in 36.8%. As a result of evaluating the reporting quality, 22 to 15 (average 18.6) items out of 27 items (81.5 to 55.6%) were reported. Conclusions: The results of a systematic review are helpful in giving a high level of evidence. In order to improve the quality of systematic reviews published in the Journal of Korean Obstetrics and Gynecology, it is necessary to perform and report according to the the PRISMA checklist and AMSTAR 2.
지백지황환·대보음환 병용투여를 통한 성조숙증 치료에 대한 체계적 문헌고찰 및 메타분석
강소현 ( So-hyeon Kang ),서지혜 ( Ji-hye Seo ),허다희 ( Da-hee Hur ),이동녕 ( Dong-nyung Lee ),김형준 ( Hyeong-jun Kim ) 대한한방부인과학회 2021 大韓韓方婦人科學會誌 Vol.34 No.2
Objectives: The purpose of this study is to assess the efficacy of Jibaekjihwang-hwan and Daeboeum-hwan combination therapy for the treatment of precocious puberty. Methods: 6 databases were searched from the date of inception until April 2021 for relevant studies. We included randomized controlled trials (RCTs) and non-randomized controlled trials (nRCTs) which focused on effects of Jibaekjihwang-hwan and Daeboeum-hwan on precocious puberty. Results: Total 8 literatures were included in qualitative analysis and meta analysis on results was conducted on 4 synthesizable studies. The response rate was significantly higher in Jibaekjihwang-hwan and Daeboeum-hwan combination group than in conventional therapy group. Also, serum estradiol and follicle stimulating hormone (FSH) level were significantly lower in Jibaekjihwang-hwan and Daeboeum-hwan combination group than in conventional therapy group. Conclusions: It seems that combination therapy of Jibaekjihwang-hwan and Daeboeum-hwan can effectively reduce serum estradiol and FSH level while increasing response rate significantly. Further high quality studies are needed to supplement the efficacy and safety of combination therapy of Jibaekjihwang-hwan and Daeboeum-hwan on precocious puberty.