http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
트란스페린에 대한 단클론항체의 생산과 방사면역측정법의 개발
한현식,곽상준 충북대학교 의과대학 충북대학교 의학연구소 1997 忠北醫大學術誌 Vol.7 No.1
트란스페린은 주로 간에서 생산되는 금속결합 운반 당단백으로 주요한 역할은 헤모글로빈의 합성을 위하여 철을 운반하는 것이다. 근래 트란스페린의 철공급 외의 기능으로 감염에 대한 숙주 저항에 관한 견해들이 있다. 현재 트란스페린을 직접 측정하는 방법인 방사면역 확산법은 혈장의 농도를 측정하는 데에는 문제가 없으나 체액에 미량 존재하는 부위의 측정에는 민감도가 떨어진다. 본연구에서는 트란스페린에 대한 단클론항체를 만들어 이들의 특성을 분석하고, 이를 이용한 민감한 측정법을 개발하며, 나아가 트란스페린치와 숙주저항성과의 관련성을 보고자 하였다. 단글론항체를 3가지 얻었는데, 이들은 모두 IgG₁이었고 이항체는 트란스페린의 철결합 유무에 관계 없이 같은 정도로 결합하였다. 트란스페린의 항원결정기는 서로 같거나 아주 근접하여 위치하는 것으로 생각 된다. 트란스페린을 방사성옥소로 표식하고, 폴리스타이린관을 고상으로 이용한 면역측정법을 개발하였는데, 검색구간은 0.1 - 20 ㎍/㎖ 이었고, 정밀도 및 분석적 회수율이 높았다. 혈청은 1,000배로 희석하여 측정하고, 소변은 희석하지 않고 측정할 수 있었다. 급성 감염성 질환과 비염증성 질환에서 얻은 혈청과 소변의 트란스페린치를 측정한 결과 유의한 차이를 보이지는 않았다 Transferrin is a metal-binding transport glycoprotein mainly produced in the liver. In addition to the iron supplying function, host resistance to infection of transferrin has been recently proposed. Transferrin is currently measured by radial immunodiffusion, but its sensitivity is low, especially for assaying body fluid other than serum. For developing a more sensitive assay system, monoclonal antibodies to human transferrin were produced, all of which are of the IgG₁subclass. These monoclonal antibodies bound transferrin to the same degree regardless of iron binding. The epitopes of transferrin seemed to be nearly the same or very close in position, so that competitive binding immunoassay system was developed in which transferrin was labelled with I125 and polystyrene tube was used as a solid phase. The detectable rang of transferrin by the assay system was between 0.1 and 20㎍/ml. The reproducibility and the recovery were satisfactory Serum was assayed after diluting 1 to 1000, but urine was assayed without dilution. The transferrin levels of acute infectious subjects were not significantly different from those of non-inflammatory subjects in urine as well as serum.
한현식(Hyunsik Han),송진우(Jinwoo Song) 한국자동차공학회 2005 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2005 No.5_1
Three-way catalysts (TWC) have been contributing to cleaning the harmful automotive emissions such as HC, CO and Nox. OSC has been regarded as the most important component in the modern TWC because it keeps the air-to-fuel ratio relatively constant at catalyst bed around the stoichiometric point in spite of highly transient real driving condition. This allows the oxidative and reductive reactions to occur simultaneously at same catalyst. The evolution of OSC has been leading the progress of modern TWC that requires high catalytic performance for more than 100,000 miles. OSC is important in both aspects of oxygen-buffer at the catalyst and promoter through the synergistic interaction with precious metals. Even though pure cerium oxide was the first component that had been commercially used, the poor thermal stability was a weak point. Composite material, such as CeO₂-ZrO₂, with higher thermal stability than pure cerium oxide has been explored to comply with ever tightening emission regulations. In this paper, the characteristics of the advanced oxygen storage component, obtained by the various characterization tools, as well as TWC using the material, obtained at engine and vehicle test benches, will be shown.
RACK ROLLING을 고려한 R/P GEAR SYSTEM 설계
한현식(Hyunsik Han),손명섭(Myungseob Son),허성무(Sean Heo) 한국자동차공학회 2020 한국자동차공학회 학술대회 및 전시회 Vol.2020 No.11
The change in energy paradigm according to global eco-friendly policies is accelerating popularization of electric vehicles, and as the time of sharing economy and autonomous car is coming, steering system is also facing new challenges. As part of that, in order to cope with increase in the weight of electric vehicles and rapid increase in mileage of autonomous vehicles, each supplier need to ensure reliability of their R/P Gear system(DP-EPS, SbW, MRP) under more severe conditions. In this paper, in order to improve the reliability of the rack(or pinion) tooth, which are the main parts of the system, a factor called ‘Stress factor’, which is independent from the contact ratio and another factors that have been used traditionally, is introduced to examine stress concentration phenomenon which is occurred on tooth by ‘Rack rolling’. The factor is validated by comparing it with our past test history, and furthermore, a review tool is created using excel so that engineers can use it easily. By confirming the durability of the gear in advance through this paper, reliable data can be presented when trying to receive contracts, and time and cost can be reduced by preventing design changes related to tooth failure that may occur during the development process.