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이미랑(Mi-Rang Lee),도경탁(Kyoung-Tag Do),한정주(Jyung-Ju Han),문소현(So-Hyun Moon),강한석(Han-Seok Kang),김선구(Seon-Ku Kim),신택순(Teak-Soon Shin),이홍구(Hong-Goo Lee),황대연(Dae-Yon Hwang),김용균(Yong-Gyun Kim),손시환(Sea-Hwan Soh 한국생명과학회 2009 생명과학회지 Vol.19 No.10
Telomeres, comprised of tandem repeats of TTAGGG sequences, are special nucleoprotein structures that protect and stabilize chromosome ends. These structures form the crux of the telomere concept of aging, senescence and genomic instability. The classic terminal restriction fragment (TRF) analysis to quantify the amount of telomeric DNA is disadvantageous in species containing ultra long telomeres like in mice (100Kb). In this study, we used a more sensitive quantitative fluorescence in situ hybridization (Q FISH) technique to quantify telomeric DNA, and used it as a biological aging marker in mice. 12 litters each of Senescence-Resistant (SAMR1) and ?Prone (SAMP1) known as senescence accelerated mouse strains were purchased from Central Lab, Animal Inc. We quantified the amount of telomeric DNA using telomere specific DNA probes on the two strains of male mice at 8 weeks, 18 weeks and 26 weeks of age. The amount of telomeric DNA correlated with aging and age associated changes in body and organ weight between SAMR1 and SAMP1 strains of mice. These data suggest the usefulness of the amount of telomeric DNA as a biological aging marker in human aging studies.